Evidence map›Paper›PMID 35304655›Full record

SynthesisCancer causes & control : CCC2022

Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.

Samantha Morais, Adriana Costa, Gabriela Albuquerque, Natália Araújo, Claudio Pelucchi, Charles S Rabkin, Linda M Liao, Rashmi Sinha, Zuo-Feng Zhang, Jinfu Hu and 33 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Cancer causes & control : CCC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Cancer mortality predictions for 2026 in selected Asian countries and Australia with focus on prostate cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
    Article
  6. Review
  7. Article
  8. The descriptive epidemiology of gastric cancer in Afghanistan: a population-based cancer registry, 2018-2020.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Environmental factors in gastric carcinogenesis and preventive intervention strategies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 20 institutions in 12 countries.

Samantha MoraisEPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Adriana CostaEPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Gabriela AlbuquerqueEPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Natália AraújoEPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Claudio PelucchiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Jinfu HuHarbin Medical University, Harbin, China.
Kenneth C JohnsonSchool of Epidemiology and Public Health, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
Monica FerraroniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Rossella BonziDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Guo-Pei YuMedical Informatics Center, Peking University, Peking, China.
Lizbeth López-CarrilloMexico National Institute of Public Health, Morelos, Mexico.
Reza MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Akihisa HidakaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Gerson Shigueaki HamadaNikkei Disease Prevention Center, São Paulo, Brazil.
David ZaridzeDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
Dmitry MaximovitchDepartment of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
Jesus VioqueConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Manoli García de la HeraConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Victor MorenoConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Mercedes Vanaclocha-EspiCancer and Public Health Area, FISABIO - Public Health, Valencia, Spain.
Mary H WardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Mohammadreza PaksereshtDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Raúl Ulises Hernández-RamirezDepartment of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, CT, USA.
Malaquias López-CervantesFacultad de Medicina, UNAM, Coyoacán, Mexico.
Farhad PourfarziDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Lina MuDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Robert C KurtzDepartment of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.
Stefania BocciaSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberta PastorinoSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Areti LagiouDepartment of Public and Community Health, School of Health Sciences, University of West Attica, Egaleo, Greece.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
M Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Maria Paula CuradoCentro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil.
Eva NegriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Nuno LunetEPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal. nlunet@med.up.pt.
Division of Cancer Epidemiology and GeneticsUniversidade do Porto · PTUniversity of Milan · ITInstituto de investigación sanitaria y biomédica de AlicanteRussian Cancer Research Center NN Blokhin · RUUniversità Cattolica del Sacro Cuore · ITAC Camargo Hospital · BRArdabil University of Medical Sciences · IRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESHarbin Medical University · CNHarvard University · USMemorial Sloan Kettering Cancer Center · USPeking University · CNPiedmont Reference Center for Epidemiology and Cancer Prevention · ITStony Brook University · USTehran University of Medical Sciences · IRUCLA Health · USUniversidad Nacional Autónoma de México · MXUniversity at Buffalo, State University of New York · US

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca grant 2017SGR723Associazione Italiana per la Ricerca sul Cancro Project no. 21378FCT POCI-01-0145-FEDER-032358FCT ref. PTDC/SAU-EPI/32358/2017FCT UIDB/04750/2020FCT & POCH/FSE SFRH/BD/119390/2016
6 · The paper itself

Abstract

purposePrevious studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between total salt or added salt and gastric cancer are less consistent and vary with the exposure considered. This study aimed to quantify the association between dietary salt exposure and gastric cancer, using an individual participant data meta-analysis of studies participating in the Stomach cancer Pooling (StoP) Project.

methodsData from 25 studies (10,283 cases and 24,643 controls) from the StoP Project with information on salt taste preference (tasteless, normal, salty), use of table salt (never, sometimes, always), total sodium intake (tertiles of grams/day), and high-salt and salt-preserved foods intake (tertiles of grams/day) were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age, and gastric cancer risk factors) odds ratios (aORs), and the corresponding 95% confidence intervals (95% CI).

resultsGastric cancer risk was higher for salty taste preference (aOR 1.59, 95% CI 1.25-2.03), always using table salt (aOR 1.33, 95% CI 1.16-1.54), and for the highest tertile of high-salt and salt-preserved foods intake (aOR 1.24, 95% CI 1.01-1.51) vs. the lowest tertile. No significant association was observed for the highest vs. the lowest tertile of total sodium intake (aOR 1.08, 95% CI 0.82-1.43). The results obtained were consistent across anatomic sites, strata of Helicobacter pylori infection, and sociodemographic, lifestyle and study characteristics.

conclusionSalty taste preference, always using table salt, and a greater high-salt and salt-preserved foods intake increased the risk of gastric cancer, though the association was less robust with total sodium intake.

Indexed as

Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsCase-Control StudiesHumansRisk FactorsSodium Chloride, DietarySodium Chloride, DietaryConsortiumPooled analysisSodium chlorideSodium, DietaryStomach neoplasms

Identifiers

PMID35304655
OpenAlexW4220922773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.