ArticleNPJ Parkinson's disease2022
The emerging postural instability phenotype in idiopathic Parkinson disease.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson's disease: a proof-of-concept study.Journal of neuroengineering and rehabilitation · 2025Trial
- Integrated In Vivo and In Vitro Analysis of Alpha-Synuclein Aggregation and Neuroinflammatory Amplification in a Composite Parkinson's Disease Model.Neurochemical research · 2026Article
- Survival after Subthalamic Deep Brain Stimulation for Parkinson's Disease: 25-Year Experience from a Single Center.Movement disorders clinical practice · 2026Article
- Sensor-Derived Parameters from Standardized Walking Tasks Can Support the Identification of Patients with Parkinson's Disease at Risk of Gait Deterioration.Bioengineering (Basel, Switzerland) · 2026Article
- Neuropsychological aspects of impulse control disorders in Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Identifying and predicting fast versus slow Parkinson's disease motor progressors using clinical and digital data.BMJ neurology open · 2026Article
- Lithium as a disease-modifying therapy for Parkinson's disease: mechanisms, preclinical evidence, and clinical prospects.Clinical parkinsonism & related disorders · 2026Review
- The patient-centric development of an inclusive multi-arm multi-stage trial for Parkinson's disease.Brain communications · 2026Article
- Chronic Pain in Parkinson's Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities.Annals of clinical and translational neurology · 2025Article
- Gait and balance dysfunction are associated with cognitive performance only in men with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Modeling and validation of wearable sensor-based gait parameters in Parkinson's disease patients with cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Diffusion tensor metrics, motor and non-motor symptoms in de novo Parkinson's disease.Neuroradiology · 2024Article
- Neuroimaging correlates of postural instability in Parkinson's disease.Journal of neurology · 2024Article
- Integrating Big Data, Artificial Intelligence, and motion analysis for emerging precision medicine applications in Parkinson's Disease.Journal of big data · 2024Article
- Early dopaminergic replacement treatment initiation benefits motor symptoms in patients with Parkinson's disease.Frontiers in human neuroscience · 2024Article
- Article
- Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson's disease subtypes.Frontiers in neurology · 2023Article
- Magnetic Resonance Planimetry in the Differential Diagnosis between Parkinson's Disease and Progressive Supranuclear Palsy.Brain sciences · 2022Review
- Article
- Spinal cord stimulation therapy for patients with Parkinson's disease and gait problems (STEP-PD): study protocol for an exploratory, double-blind, randomised, placebo-controlled feasibility trial.BMJ neurology open · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Identification of individuals at high risk for rapid progression of motor and cognitive signs in Parkinson disease (PD) is clinically significant. Postural instability and gait dysfunction (PIGD) are associated with greater motor and cognitive deterioration. We examined the relationship between baseline clinical factors and the development of postural instability using 5-year longitudinal de-novo idiopathic data (n = 301) from the Parkinson's Progressive Markers Initiative (PPMI). Logistic regression analysis revealed baseline features associated with future postural instability, and we designated this cohort the emerging postural instability (ePI) phenotype. We evaluated the resulting ePI phenotype rating scale validity in two held-out populations which showed a significantly higher risk of postural instability. Emerging PI phenotype was identified before onset of postural instability in 289 of 301 paired comparisons, with a median progression time of 972 days. Baseline cognitive performance was similar but declined more rapidly in ePI phenotype. We provide an ePI phenotype rating scale (ePIRS) for evaluation of individual risk at baseline for progression to postural instability.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.