Evidence map›Paper›PMID 35304460›Full record

ArticleNature communications2022

Large field-of-view non-invasive imaging through scattering layers using fluctuating random illumination.

Lei Zhu, Fernando Soldevila, Claudio Moretti, Alexandra d'Arco, Antoine Boniface, Xiaopeng Shao, Hilton B de Aguiar, Sylvain Gigan

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  16. Speckle-correlation imaging through a kaleidoscopic multimode fiber.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lei ZhuLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.
Fernando SoldevilaLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.
Claudio MorettiLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.ORCID 0000-0002-7636-7736
Alexandra d'ArcoLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.
Antoine BonifaceLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.
Xiaopeng ShaoSchool of Physics and Optoelectronic Engineering, Xidian University, Xi'an, 710071, China.
Hilton B de AguiarLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France.
Sylvain GiganLaboratoire Kastler Brossel, ENS-Université PSL, CNRS, Sorbonne Université, College de France, 24 Rue Lhomond, F-75005, Paris, France. sylvain.gigan@lkb.ens.fr.ORCID 0000-0002-9914-6231

Funding

In vivo Imaging of Neuroactivity in the Deep Forward Scattering Regime Using Speckle Identification and Demixing (SPID) MicroscopyRF1NS113251 · NINDS · ROCKEFELLER UNIVERSITY · PI GIGAN, SYLVAIN, VAZIRI, ALIPASHA · 2019 to 2019
$2.1M
NINDS NIH HHS RF1 NS113251
6 · The paper itself

Abstract

Non-invasive optical imaging techniques are essential diagnostic tools in many fields. Although various recent methods have been proposed to utilize and control light in multiple scattering media, non-invasive optical imaging through and inside scattering layers across a large field of view remains elusive due to the physical limits set by the optical memory effect, especially without wavefront shaping techniques. Here, we demonstrate an approach that enables non-invasive fluorescence imaging behind scattering layers with field-of-views extending well beyond the optical memory effect. The method consists in demixing the speckle patterns emitted by a fluorescent object under variable unknown random illumination, using matrix factorization and a novel fingerprint-based reconstruction. Experimental validation shows the efficiency and robustness of the method with various fluorescent samples, covering a field of view up to three times the optical memory effect range. Our non-invasive imaging technique is simple, neither requires a spatial light modulator nor a guide star, and can be generalized to a wide range of incoherent contrast mechanisms and illumination schemes.

Indexed as

LightingOptical Imaging

Identifiers

PMID35304460
PMCPMC8933547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.