Evidence map›Paper›PMID 35304427›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Thoracic VGluT2

Benjamin T Noble, Faith H Brennan, Yan Wang, Zhen Guan, Xiaokui Mo, Jan M Schwab, Phillip G Popovich

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Neuroplasticity and regeneration after spinal cord injury.North American Spine Society journal · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benjamin T NobleDepartment of Neuroscience, Center for Brain and Spinal Cord Repair, Belford Center for Spinal Cord Injury, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Faith H BrennanDepartment of Neuroscience, Center for Brain and Spinal Cord Repair, Belford Center for Spinal Cord Injury, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.ORCID https://orcid.org/0000-0002-9201-2476
Yan WangDepartment of Neuroscience, Center for Brain and Spinal Cord Repair, Belford Center for Spinal Cord Injury, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Zhen GuanDepartment of Neuroscience, Center for Brain and Spinal Cord Repair, Belford Center for Spinal Cord Injury, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.
Xiaokui MoCenter for Biostatistics, The Ohio State University, Columbus, Ohio 43210.
Jan M SchwabDepartment of Neurology, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210.ORCID https://orcid.org/0000-0001-6784-4919
Phillip G PopovichDepartment of Neuroscience, Center for Brain and Spinal Cord Repair, Belford Center for Spinal Cord Injury, Wexner Medical Center, The Ohio State University, Columbus, Ohio 43210 phillip.popovich@osumc.edu.ORCID https://orcid.org/0000-0003-1329-7395
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
Overcoming Neurogenic “Meta-Inflammation” to Promote Recovery After Spinal Cord InjuryR35NS111582 · NINDS · OHIO STATE UNIVERSITY · PI PHILLIP G POPOVICH · 2019 to 2026
$8.7M
Preventing autonomic dysreflexia to restore immune function after SCIR01NS083942 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2014 to 2018
$2.2M
Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Reducing Infection Susceptibility by Immune Function Restoration in Spinal Cord InjuryR01NS118200 · NINDS · OHIO STATE UNIVERSITY · PI SCHWAB, JAN · 2020 to 2024
$1.9M
Role of the spinal cord - gut - immune axis after spinal cord injuryR01NS099532 · NINDS · OHIO STATE UNIVERSITY · PI POPOVICH, PHILLIP G · 2017 to 2018
$1.0M
ACL HHS 90SI5020NIH HHS P40 OD010996NINDS NIH HHS P30 NS104177NINDS NIH HHS R01 NS083942NINDS NIH HHS R01 NS099532NINDS NIH HHS R01 NS118200NINDS NIH HHS R35 NS111582
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) above the major spinal sympathetic outflow (T6 level) disinhibits sympathetic neurons from supraspinal control, causing systems-wide "dysautonomia." We recently showed that remarkable structural remodeling and plasticity occurs within spinal sympathetic circuitry, creating abnormal sympathetic reflexes that exacerbate dysautonomia over time. As an example, thoracic VGluT2

Indexed as

Autonomic DysreflexiaPrimary DysautonomiasSpinal Cord InjuriesAnimalsFemaleHumansInterneuronsMaleMiceSpinal Cord

Identifiers

PMID35304427
PMCPMC9053847
OpenAlexW4220918203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.