Evidence map›Paper›PMID 35304171›Full record

ReviewAdvanced drug delivery reviews2022

Immunoengineering strategies to enhance vascularization and tissue regeneration.

Jana Zarubova, Mohammad M Hasani-Sadrabadi, Reza Ardehali, Song Li

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jana ZarubovaDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Prague 14220, Czech Republic.
Mohammad M Hasani-SadrabadiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Reza ArdehaliDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Song LiDepartment of Bioengineering, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: songli@ucla.edu.
Broad Center · USUniversity of California, Los Angeles · US

Funding

Surgical Microneedle Patch Delivery of CMMP for Heart RepairR01HL149940 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2020 to 2023
$3.0M
Generation of mature human embryonic stem cell-derived left ventricular cardiomyocytes for transplantation in a large animal modelR01HL148714 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDEHALI, REZA · 2019 to 2022
$2.2M
Towards Glucose Transporter-Mediated Glucose-Responsive Insulin Delivery with Fast ResponseR01DK112939 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2018 to 2022
$2.2M
Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
Therapeutic microneedles for localized treatment of periodontal tissueR56DE029157 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2019
$286k
NCI NIH HHS R01 CA234343NHLBI NIH HHS R01 HL148714NHLBI NIH HHS R01 HL149940NIDCR NIH HHS R56 DE029157NIDDK NIH HHS R01 DK112939
6 · The paper itself

Abstract

Immune cells have emerged as powerful regulators of regenerative as well as pathological processes. The vast majority of regenerative immunoengineering efforts have focused on macrophages; however, growing evidence suggests that other cells of both the innate and adaptive immune system are as important for successful revascularization and tissue repair. Moreover, spatiotemporal regulation of immune cells and their signaling have a significant impact on the regeneration speed and the extent of functional recovery. In this review, we summarize the contribution of different types of immune cells to the healing process and discuss ways to manipulate and control immune cells in favor of vascularization and tissue regeneration. In addition to cell delivery and cell-free therapies using extracellular vesicles, we discuss in situ strategies and engineering approaches to attract specific types of immune cells and modulate their phenotypes. This field is making advances to uncover the extraordinary potential of immune cells and their secretome in the regulation of vascularization and tissue remodeling. Understanding the principles of immunoregulation will help us design advanced immunoengineering platforms to harness their power for tissue regeneration.

Indexed as

MacrophagesWound HealingBiocompatible MaterialsHumansImmunityBiocompatible MaterialsBiomaterialCell deliveryExtracellular vesiclesImmune cell metabolismImmunomodulationMacrophagesNeutrophilsPatterningStiffnessT cells

Identifiers

PMID35304171
PMCPMC10726003
OpenAlexW4220911943

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.