ArticleJournal of molecular and cellular cardiology2022
EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia.
Open access · greenAbstract read
In one paragraph
Article in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Excessive EFHD1-dependent ER-mitochondrial contacts drive a maladaptive antiviral response in metabolic liver disease.The Journal of clinical investigation · 2026Article
- Matrix polyamines regulate bidirectional calcium flux through MCU.Structure (London, England : 1993) · 2026Article
- Linking Mitochondrial Dysfunction to the Immune Microenvironment in HFpEF: An Integrated Bioinformatics and Experimental Approach.Immunity, inflammation and disease · 2026Article
- Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026Review
- Excessive CabioRxiv : the preprint server for biology · 2026Article
- Epigenome-Wide Association Studies of Proteasome Inhibitor-Related Cardiotoxicity in Patients with Multiple Myeloma.Cancers · 2026Article
- The Function ofbioRxiv : the preprint server for biology · 2026Article
- Sevoflurane induces CaCytotechnology · 2025Article
- Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.Circulation research · 2025Article
- The role of mitochondrial dysfunction in the pathogenesis of atherosclerosis: A new exploration from bioinformatics analysis.Medicine · 2025Article
- Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake.Journal of cellular physiology · 2025Article
- Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells.Journal of visualized experiments : JoVE · 2025Article
- Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks.The EMBO journal · 2024Article
- Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024Review
- Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.bioRxiv : the preprint server for biology · 2024Article
- Identification of novel genetic loci related to dromedary camel (Camelus dromedarius) morphometrics, biomechanics, and behavior by genome-wide association studies.BMC veterinary research · 2024Article
- Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.Physiology (Bethesda, Md.) · 2024Review
- Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart.JCI insight · 2024Article
- SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.Basic research in cardiology · 2023Article
- EFHD1, a novel mitochondrial regulator of tumor metastasis in clear cell renal cell carcinoma.Cancer science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
David R EberhardtNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Sandra H LeeNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Xue YinNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Anthony M BalynasNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Emma C RekateNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Jackie N KraissNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America.
Marisa J LangDiabetes & Metabolism Research Center, University of Utah, United States of America.
Maureen A WalshDiabetes & Metabolism Research Center, University of Utah, United States of America.
Molly E StreiffNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America; Department of Biomedical Engineering, University of Utah, United States of America.
Andrea C CorbinNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America; Department of Biomedical Engineering, University of Utah, United States of America.
Ying LiNutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States of America.
Katsuhiko FunaiDiabetes & Metabolism Research Center, University of Utah, United States of America.
Frank B SachseNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America; Department of Biomedical Engineering, University of Utah, United States of America.
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, United States of America; Department of Biomedical Engineering, University of Utah, United States of America; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States of America. Electronic address: dipayan.chaudhuri@hsc.utah.edu.
Harrison Medical Center · USUniversity of Utah · US
Funding
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MInterdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8MMetabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3MPE methylation in skeletal muscle energy efficiencyR01DK107397 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2017 to 2025
$3.8MLOOH-induced muscle atrophy with ageR01AG074535 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Micah J Drummond, Katsuhiko Funai · 2022 to 2026
$3.0MLands cycle and skeletal muscle insulin actionR01DK127979 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2022 to 2025
$1.9MPE In Modulation of Energy Flux Through OxphosR01GM144613 · NIGMS · UNIVERSITY OF UTAH · PI FUNAI, KATSUHIKO · 2021 to 2024
$1.6MNHLBI NIH HHS R01 HL141353NIA NIH HHS R01 AG074535NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK107397NIDDK NIH HHS R01 DK127979NIDDK NIH HHS T32 DK091317NIGMS NIH HHS R01 GM144613
Abstract
Altered levels of intracellular calcium (Ca
Indexed as
Myocardial Reperfusion InjuryMyocytes, CardiacAnimalsCalciumIschemiaMiceMitochondria, HeartReactive Oxygen SpeciesCalciumReactive Oxygen SpeciesHypoxiaIschemia reperfusionMitocalcinMitochondriaMitochondrial calcium transportMitochondrial outer membranePermeability transitionReactive oxygen speciesSwiprosin-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.