Evidence map›Paper›PMID 35304006›Full record

ArticleUltrasound in medicine & biology2022

Therapeutic Ultrasound Effects on Human Induced Pluripotent Stem Cell Cardiomyocytes Measured Optically and with Spectral Ultrasound.

Andrew W Chen, George Saab, Aleksandar Jeremic, Vesna Zderic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. [Current status of intrauterine adhesion treatment and research progress in stem cell therapy].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew W ChenDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA. Electronic address: andrewchen@gwu.edu.
George SaabDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Aleksandar JeremicDepartment of Biological Sciences, The George Washington University, Washington, DC, USA.
Vesna ZdericDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
George Washington University · US

Funding

Low-intensity ultrasound for control of cardiac electromechanics: a mechanistic investigation.R21EB026152 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ENTCHEVA, EMILIA, ZDERIC, VESNA · 2018 to 2019
$439k
NIBIB NIH HHS R21 EB026152
6 · The paper itself

Abstract

To the best of our knowledge, therapeutic ultrasound (TUS) is thus far an unexplored means of delivering mechanical stimulation to cardiomyocyte cultures, which is necessary to engineer a more mature cardiomyocyte phenotype in vitro. Spectral ultrasound (SUS) may provide a way to non-invasively, non-disruptively and inexpensively monitor growth and change in cell cultures over long periods. Compared with other measurement methods, SUS as an acoustic measurement tool will not be affected by an acoustic therapy, unlike electrical measurement methods, in which motion caused by acoustic therapy can affect measurements. Further SUS has the potential to provide functional as well as morphological information in cell cultures. Human induced pluripotent stem cell cardiomyocytes (iPS-CMs) were imaged with calcium fluorescence microscopy while TUS was being applied. TUS was applied at 600 kHz and 1, 3.4 and 6 W/cm

Indexed as

Induced Pluripotent Stem CellsUltrasonic TherapyCalciumHumansMyocytes, CardiacUltrasonographyCalciumCardiomyocytesInduced pluripotent stem cell cardiomyocytesSpectral ultrasoundTherapeutic ultrasound

Identifiers

PMID35304006
PMCPMC9179027
OpenAlexW4220975786

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.