Evidence map›Paper›PMID 35303939›Full record

Observational studyAntimicrobial resistance and infection control2022

Occupational and community risk of SARS-CoV-2 infection among employees of a long-term care facility: an observational study.

Lauriane Lenggenhager, Romain Martischang, Julien Sauser, Monica Perez, Laure Vieux, Christophe Graf, Samuel Cordey, Florian Laubscher, Tomás Robalo Nunes, Walter Zingg and 3 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Antimicrobial resistance and infection control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Lauriane LenggenhagerInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland. Lauriane.Lenggenhager@hcuge.ch.ORCID 0000-0001-8669-643X
Romain MartischangInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
Julien SauserInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
Monica PerezInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
Laure VieuxOccupational Health Service, Geneva University Hospitals, Geneva, Switzerland.
Christophe GrafDepartment of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland.
Samuel CordeyFaculty of Medicine, University of Geneva, Geneva, Switzerland.
Florian LaubscherLaboratory of Virology, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.
Tomás Robalo NunesInfectious Diseases Service of Hospital Garcia de Orta, EPE, Almada, Portugal.
Walter ZinggInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
Anne CoriMRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Stephan HarbarthInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
Mohamed AbbasInfection Control Programme, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland.
University Hospital of Geneva · CHUniversity of Geneva · CHHospital Garcia de Orta · PTImperial College London · GB

Funding

Medical Research Council MR/R015600/1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31CA30_196197Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 4078P0_198363
6 · The paper itself

Abstract

backgroundWe investigated the contribution of both occupational and community exposure for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among employees of a university-affiliated long-term care facility (LTCF), during the 1

methodsWe performed a nested analysis of a seroprevalence study among all volunteering LTCF staff to determine community and nosocomial risk factors for SARS-CoV-2 seropositivity using modified Poison regression. We also combined epidemiological and genetic sequencing data from a coronavirus disease 2019 (COVID-19) outbreak investigation in a LTCF ward to infer transmission dynamics and acquisition routes of SARS-CoV-2, and evaluated strain relatedness using a maximum likelihood phylogenetic tree.

resultsAmong 285 LTCF employees, 176 participated in the seroprevalence study, of whom 30 (17%) were seropositive for SARS-CoV-2. Most (141/176, 80%) were healthcare workers (HCWs). Risk factors for seropositivity included exposure to a COVID-19 inpatient (adjusted prevalence ratio [aPR] 2.6; 95% CI 0.9-8.1) and community contact with a COVID-19 case (aPR 1.7; 95% CI 0.8-3.5). Among 18 employees included in the outbreak investigation, the outbreak reconstruction suggests 4 likely importation events by HCWs with secondary transmissions to other HCWs and patients.

conclusionsThese two complementary epidemiologic and molecular approaches suggest a substantial contribution of both occupational and community exposures to COVID-19 risk among HCWs in LTCFs. These data may help to better assess the importance of occupational health hazards and related legal implications during the COVID-19 pandemic.

Indexed as

COVID-19HumansLong-Term CareNursing HomesPandemicsPhylogenySARS-CoV-2Seroepidemiologic StudiesCOVID-19Nosocomial outbreaksOccupational exposureSARS-CoV-2

Identifiers

PMID35303939
PMCPMC8931578
OpenAlexW4220938830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.