ArticleCardiovascular diabetology2022
Triglyceride-glucose index and common carotid artery intima-media thickness in patients with ischemic stroke.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Metformin on CIMT and FMD in PCOS patients: a systematic review and meta-analysis.BMC women's health · 2024Pooled it
- Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.European journal of nutrition · 2024Trial
- Trial
- Correlation between surrogate indicators of insulin resistance and all-cause mortality in patients with severe hemorrhagic stroke: a multicenter retrospective cohort study in the United States.Cardiovascular diabetology · 2026Article
- Sex-specific performance of composite metabolic-adiposity indices in identifying hypertension and carotid atherosclerosis: a cross-sectional study of 154,873 Chinese adults.Scientific reports · 2026Article
- The joint association of the combined triglyceride-glucose index and atherogenic index of plasma with hypertension on stroke risk across different glycemic status: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Lipidomic profiling identifies key pathways and a 5-lipid panel with high diagnostic efficacy for ischemic stroke.Scientific reports · 2026Article
- Post-procedural hemodynamics by quantitative DSA predict restenosis in chronic internal carotid artery occlusion.Neuroradiology · 2026Article
- Association of triglyceride-glucose index with carotid atherosclerosis in the general population: a case-control study of 14,535 participants.BMC cardiovascular disorders · 2026Article
- Exploring the interaction between klotho and TyG index in cardiovascular risk stratification: A metabolic-inflammatory network analysis with mediation and machine learning insights.American heart journal plus : cardiology research and practice · 2026Article
- Article
- Triglyceride-glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride-glucose strata.BMC cardiovascular disorders · 2025Article
- The Triglyceride Glucose-Conicity Index as a Novel Predictor for Stroke Risk: A Nationwide Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2025Article
- Observational
- Triglyceride-glucose index: a novel assessment tool for all-cause mortality in critical stroke patients-a retrospective analysis of the eICU-CRD database.Cardiovascular diabetology · 2025Observational
- Triglyceride-glucose index combined with body roundness index predicts cardiovascular risk in middle-aged and elderly individuals: a 10-year cohort study.Scientific reports · 2025Article
- Article
- Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke.Cardiovascular diabetology · 2025Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
backgroundTriglyceride glucose (TyG) index was recently reported to be associated with an increased risk of the development and recurrence of cardiovascular events, and atherosclerosis is a main speculative mechanism. However, data on the relationship between TyG index and atherosclerosis, especially in the setting of ischemic stroke, is rare. We aimed to explore the association between TyG index and carotid atherosclerosis in patients with ischemic stroke.
methodsA total of 1523 ischemic stroke patients with TyG index and carotid artery imaging data were enrolled in this analysis. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Carotid atherosclerosis was measured by common carotid artery intima-media thickness (cIMT), and abnormal cIMT was defined as a mean cIMT and maximum cIMT value ≥ 1 mm. Multivariable logistic regression models and restricted cubic spline models were used to assess the relationships between TyG index and abnormal cIMT. Risk reclassification and calibration of models with TyG index were analyzed.
resultsThe multivariable-adjusted odds ratios (95% CIs) in quartile 4 versus quartile 1 of TyG index were 1.56 (1.06-2.28) for abnormal mean cIMT and 1.46 (1.02-2.08) for abnormal maximum cIMT, respectively. There were linear relationships between TyG index and abnormal mean cIMT (P for linearity = 0.005) and abnormal maximum cIMT (P for linearity = 0.027). In addition, the TyG index provided incremental predictive capacity beyond established risk factors, shown by an increase in net reclassification improvement and integrated discrimination improvement (all P < 0.05).
conclusionsA higher TyG index was associated with carotid atherosclerosis measured by cIMT in patients with ischemic stroke, suggesting that TyG could be a promising atherosclerotic marker.
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