Evidence map›Paper›PMID 35303789›Full record

ReviewAnnual review of biochemistry2022

Managing the Steady State Chromatin Landscape by Nucleosome Dynamics.

Kami Ahmad, Steven Henikoff, Srinivas Ramachandran

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Rotational settings quantize nucleosome movement by chromatin regulators.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Nucleosomal DNA has topological memory.Nature communications · 2024
    Article
  6. Article
  7. Review
  8. The functional decline of tomato plants infected byFrontiers in plant science · 2024
    Article
  9. Epigenetic insights into Fragile X Syndrome.Frontiers in cell and developmental biology · 2024
    Review
  10. Epigenetic regulation in adult neural stem cells.Frontiers in cell and developmental biology · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kami AhmadBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; email: kahmad@fredhutch.org.
Steven HenikoffBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; email: kahmad@fredhutch.org.
Srinivas RamachandranDepartment of Biochemistry and Molecular Genetics and RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado, USA.
Fred Hutch Cancer Center · USHoward Hughes Medical Institute · USUniversity of Colorado Denver · US

Funding

Maintenance of cellular memory through replicationR35GM133434 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI RAMACHANDRAN, SRINIVAS · 2019 to 2023
$2.0M
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM133434
6 · The paper itself

Abstract

Gene regulation arises out of dynamic competition between nucleosomes, transcription factors, and other chromatin proteins for the opportunity to bind genomic DNA. The timescales of nucleosome assembly and binding of factors to DNA determine the outcomes of this competition at any given locus. Here, we review how these properties of chromatin proteins and the interplay between the dynamics of different factors are critical for gene regulation. We discuss how molecular structures of large chromatin-associated complexes, kinetic measurements, and high resolution mapping of protein-DNA complexes in vivo set the boundary conditions for chromatin dynamics, leading to models of how the steady state behaviors of regulatory elements arise.

Indexed as

ChromatinNucleosomesChromatin Assembly and DisassemblyDNATranscription FactorsChromatinDNANucleosomesTranscription Factorschromatinchromatin remodelersnucleosomeRNAPIItimetranscription factors

Identifiers

PMID35303789
PMCPMC10277172
OpenAlexW4220783006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.