Evidence map›Paper›PMID 35303784›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Profiling of Protein Adducts of Estrogen Quinones in 5-Year Survivors of Breast Cancer Without Recurrence.

Che Lin, Ding-Ru Chen, Shou-Jen Kuo, Chi-Yen Feng, Dar-Ren Chen, Wei-Chung Hsieh, Po-Hsiung Lin

Open access · goldAbstract read
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Che LinComprehensive Breast Cancer Center, 36596Changhua Christian Hospital, Changhua, Taiwan.
Ding-Ru ChenComprehensive Breast Cancer Center, 36596Changhua Christian Hospital, Changhua, Taiwan.
Shou-Jen KuoComprehensive Breast Cancer Center, 36596Changhua Christian Hospital, Changhua, Taiwan.
Chi-Yen FengDepartment of Surgery, 89578Da-Chien Health Medical System, Taiwan.
Dar-Ren ChenComprehensive Breast Cancer Center, 36596Changhua Christian Hospital, Changhua, Taiwan.ORCID https://orcid.org/0000-0002-0897-4374
Wei-Chung HsiehDepartment of Laboratory Medicine, 384207Da-Chien General Hospital, Miaoli, Taiwan.
Po-Hsiung LinDepartment of Environmental Engineering, 34916National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0000-0003-1905-2778
Changhua Christian Hospital · TWChung Hwa University of Medical Technology · TWNational Chung Hsing University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study was to simultaneously analyze estrogen quinone-derived adducts, including 17β-estradiol-2,3-quinone (E SETTINGS AND

designCohort STATISTICAL ANALYSIS: All data are expressed as mean ± standard deviation of three determinations. We used Student's

resultsResult confirmed that logged levels of E

conclusionsOur findings add support to the theme that hormonal therapy including aromatase inhibitors and Tamoxifen may dramatically reduce burden of estrogen quinones. We hypothesize that combination of treatment-related effects and environmental factors may modulate estrogen homeostasis and diminish the production of estrogen quinones in breast cancer patients.

Indexed as

Breast NeoplasmsEstradiolEstrogensFemaleHumansQuinonesSurvivorsEstradiolEstrogensQuinonesbiomarkerestrogen quinonehormonal therapyprotein adducts

Identifiers

PMID35303784
PMCPMC8935573
OpenAlexW4220826784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.