ArticleStem cell reports2022
Immune regulation of intestinal-stem-cell function in Drosophila.
Article in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Recognition of pathogenic bacteria by intestinal stem cells promotes adult Drosophila midgut regeneration.PLoS biology · 2026Article
- Toll signalling controls intestinal regeneration in Drosophila.Development (Cambridge, England) · 2026Article
- Evolution, multifunctionality, and agricultural potential of insect microbiomes and the holobiont concept.The ISME journal · 2026Review
- Caenorhabditis elegans as an experimental model for resilience-boosting microbiota interventions in nonmodel ectotherms.FEMS microbiology reviews · 2026Review
- Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review.Frontiers in immunology · 2026Review
- Chronic intestinal immune activation reveals separable impacts of inflammation and barrier loss on hallmarks of ageing.PloS one · 2026Article
- From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation.Frontiers in immunology · 2026Review
- Stem cell-specific NF-κB is required for stem cell survival and epithelial regeneration upon intestinal damage.Biology open · 2025Article
- Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance.PLoS pathogens · 2025Article
- The NF-κB Factor Relish maintains blood progenitor homeostasis in the developing Drosophila lymph gland.PLoS genetics · 2024Article
- Protocol to analyze Drosophila intestinal tumor cellular heterogeneity using immunofluorescence imaging and nuclear size quantification.STAR protocols · 2024Article
- Secreted novel AID/APOBEC-like deaminase 1 (SNAD1) - a new important player in fish immunology.Frontiers in immunology · 2024Review
- Early-adult methionine restriction reduces methionine sulfoxide and extends lifespan in Drosophila.Nature communications · 2023Article
- Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan.PLoS genetics · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intestinal progenitor cells integrate signals from their niche, and the gut lumen, to divide and differentiate at a rate that maintains an epithelial barrier to microbial invasion of the host interior. Despite the importance of evolutionarily conserved innate immune defenses to maintain stable host-microbe relationships, we know little about contributions of stem-cell immunity to gut homeostasis. We used Drosophila to determine the consequences of intestinal-stem-cell immune activity for epithelial homeostasis. We showed that loss of stem-cell immunity greatly impacted growth and renewal in the adult gut. In particular, we found that inhibition of stem-cell immunity impeded progenitor-cell growth and differentiation, leading to a gradual loss of stem-cell numbers with age and an impaired differentiation of mature enteroendocrine cells. Our results highlight the importance of immune signaling in stem cells for epithelial function in the adult gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.