ArticleCell2022
Mucus sialylation determines intestinal host-commensal homeostasis.
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Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 1 of them a synthesis that pooled it.
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144citing papers in PubMed, 1 pooled it
19.7field-weighted citation impact, top 1% of its field
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Who cites it
144 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.
- Cross-species systems analysis distinguishes inflammatory remodeling from primary mucus secretory failure in inflammatory bowel disease.Frontiers in immunology · 2026Pooled it
- Sialidase inhibitor modulates gut microbiota and enhances mucosal protection in the treatment of ulcerative colitis.mSystems · 2026Trial
- Zip14 (Slc39a14) metal transporter dysfunction leads toGut microbes · 2026Article
- Review
- Novel insights into immunohistochemical analysis of intrahepatic cholangiocarcinoma: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GalNAc1) as a new marker for large duct type.Virchows Archiv : an international journal of pathology · 2026Article
- Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX.Scientific reports · 2026Article
- Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.Medical review (2021) · 2026Review
- Berberrubine, a Metabolite of Berberine, Attenuates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease by Inhibiting STAT3.International journal of molecular sciences · 2026Article
- Enterococcus faecalis NBRC 100481 Protects the Intestinal Barrier via α-catenin/HMP-1 in Caenorhabditis elegans.Probiotics and antimicrobial proteins · 2026Article
- Galacto-Oligosaccharides Reshape MucinJournal of agricultural and food chemistry · 2026Article
- BIRC3 (Encoding cIAP2) Variants Result in Dysregulated RIPK1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn's Disease.Gastroenterology · 2026Article
- Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer.Cell death & disease · 2026Article
- Gastric Cancer: Pathobiology and Therapeutics.MedComm · 2026Review
- Reference-guided genome assembly of long non-coding rna transcripts reveals target genes associated with Crohn's disease.Scientific reports · 2026Article
- B3GNT7 regulates mucin glycosylation and protects against colitis and infection.bioRxiv : the preprint server for biology · 2026Article
- Mucin Type Drives Composition and Mucin Glycan Degradation of an In Vitro Synthetic Microbial Community.Environmental microbiology · 2026Article
- Effects of microplastics on the intestines.BMC gastroenterology · 2026Review
- Mucosal glycans: key drivers of the development of inflammatory bowel disease and a potential new therapeutic target.Nature reviews. Gastroenterology & hepatology · 2026Review
- Sialic acid exacerbates polycystic ovary syndrome in mice by modulating gut microbiota-mediated bile acid metabolism and FXR activation.Nature communications · 2026Article
- Maternal curcumin supplementation alleviates intestinal inflammation ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
84 more citing papers are in PubMed but not listed here.
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Authors and funding
50 authors at 18 institutions in 6 countries.
Yikun YaoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Girak KimExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Samantha ShaferMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Zuojia ChenExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Satoshi KuboMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Yanlong JiHematology/Oncology, Department of Medicine II, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.
Jialie LuoExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Weiming YangSection on Biological Chemistry, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD 20892, USA.
Sebastian P PernerHematology/Oncology, Department of Medicine II, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany.
Chrysi KanellopoulouMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Ann Y ParkMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Ping JiangMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Jian LiExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Safa BarisDivision of Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, 34722 Istanbul, Turkey; The Isil Berat Barlan Center for Translational Medicine, Marmara University, 34722 Istanbul, Turkey.
Elif Karakoc AydinerDivision of Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, 34722 Istanbul, Turkey; The Isil Berat Barlan Center for Translational Medicine, Marmara University, 34722 Istanbul, Turkey.
Deniz ErtemMarmara University School of Medicine, Division of Pediatric Gastroenterology Hepatology and Nutrition, 34854 Istanbul, Turkey.
Daniel J MulderDepartments of Pediatrics, Medicine, and Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Neil WarnerSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Anne M GriffithsSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Chani Topf-OlivestonePediatric Gastroenterology, Kaplan Medical Center, Pasternak St., POB 1, Rehovot 76100, Israel.
Michal KoriPediatric Gastroenterology, Kaplan Medical Center, Pasternak St., POB 1, Rehovot 76100, Israel.
Lael WernerInstitute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel.
Jodie OuahedDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Michael FieldDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Chengyu LiuTransgenic Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Benjamin SchwarzImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Catharine M BosioImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Sundar GanesanBiological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Jian SongLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD 20892, USA.
Henning UrlaubBioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany; Institute of Clinical Chemistry, University Medical Center Göttingen, 37075 Göttingen, Germany.
Thomas OellerichHematology/Oncology, Department of Medicine II, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany; German Cancer Consortium/German Cancer Research Center, 69120 Heidelberg, Germany.
Stacy A MalakerYale University, Department of Chemistry, New Haven, CT 06511, USA.
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA.
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford, CA 94305, USA.
Yu ZhangLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Helen MatthewsLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.
Will MontgomeryNeuro-Immune Regulome Unit, National Eye Institute, NIH, Bethesda, MD 20892, USA.
Han-Yu ShihNeuro-Immune Regulome Unit, National Eye Institute, NIH, Bethesda, MD 20892, USA.
Jiansheng JiangMolecular Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA.
Marcus JonesRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Aris BarasRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Alan ShuldinerRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Claudia Gonzaga-JaureguiRegeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA; International Laboratory for Human Genome Research, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Juriquilla, Querétaro 04510, Mexico.
Scott B SnapperDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.
Aleixo M MuiseSickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Pediatrics, IMS, and Biochemistry, University of Toronto, Toronto, ON M5G 1X8, Canada.
Dror S ShouvalInstitute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel.
Ahmet OzenThe Isil Berat Barlan Center for Translational Medicine, Marmara University, 34722 Istanbul, Turkey; Marmara University School of Medicine, Division of Pediatric Gastroenterology Hepatology and Nutrition, 34854 Istanbul, Turkey.
Kuan-Ting PanHematology/Oncology, Department of Medicine II, Johann Wolfgang Goethe University, 60590 Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany.
Chuan WuExperimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: chuan.wu@nih.gov.
Michael J LenardoMolecular Development of the Immune System Section, Laboratory of Immune System Biology, and Clinical Genomics Program, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: lenardo@nih.gov.
National Institutes of Health · USNational Cancer Institute · USGoethe University Frankfurt · DEMarmara University · TRRegeneron (United States) · USBoston Children's Hospital · USKaplan Medical Center · ILNational Eye Institute · USSchneider Children's Medical Center · ILSickKids Foundation · CAHoward Hughes Medical Institute · USNational Heart Lung and Blood Institute · USNational Institute of Allergy and Infectious Diseases · USNational Institute of Dental and Craniofacial Research · USQueen's University · CAUniversitätsmedizin Göttingen · DEUniversity of Toronto · CAYale University · US
Funding
Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1MTransgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8MImmunity to Pulmonary InfectionsZIAAI001013 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BOSIO, CATHARINE · 2009 to 2025
$18.9MCOngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8MMolecular Mechanisms and Treatment Of Autoimmunity In Man And Animal ModelsZIAAI000717 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2009 to 2025
$13.2MStructure and Function of UDP-GalNAc:polypeptide alpha-GalNAc transferasesZIADE000739 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI TABAK, LAWRENCE A. · 2012 to 2025
$12.9MGenomic regulation of immune response in neurodegeneration in miceZIAEY000569 · NEI · NATIONAL EYE INSTITUTE · PI SHIH, HAN-YU · 2020 to 2025
$10.0MIdentifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseRC2DK122532 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KLEIN, CHRISTOPH, MUISE, ALEIXO M · 2020 to 2024
$9.1MThe role of Foxo1 for intestinal epithelial cells during mucosal immune responseZIABC011755 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2017 to 2025
$4.1MT cell regulation for intestinal barrier functionZIABC011801 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2018 to 2025
$4.1MInvestigating the Surface GlycoproteomeR01CA200423 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2015 to 2026
$3.8MImmune-neuron crosstalk regulates intestinal homeostasisZIABC012034 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2021 to 2025
$2.0MIntramural NIH HHS Z01 AI000566Intramural NIH HHS ZIA DE000739Intramural NIH HHS ZIA DE000751Intramural NIH HHS ZIA EY000569NCI NIH HHS R01 CA200423NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS RC2 DK122532
Abstract
Intestinal mucus forms the first line of defense against bacterial invasion while providing nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and commensalism is unclear. We show that terminal sialylation of glycans on intestinal mucus by ST6GALNAC1 (ST6), the dominant sialyltransferase specifically expressed in goblet cells and induced by microbial pathogen-associated molecular patterns, is essential for mucus integrity and protecting against excessive bacterial proteolytic degradation. Glycoproteomic profiling and biochemical analysis of ST6 mutations identified in patients show that decreased sialylation causes defective mucus proteins and congenital inflammatory bowel disease (IBD). Mice harboring a patient ST6 mutation have compromised mucus barriers, dysbiosis, and susceptibility to intestinal inflammation. Based on our understanding of the ST6 regulatory network, we show that treatment with sialylated mucin or a Foxo3 inhibitor can ameliorate IBD.
Indexed as
Gastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsHomeostasisHumansIntestinal MucosaMiceMucusSialyltransferasesSymbiosisCMP-N-acetylneuraminate-alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferaseSialyltransferasesdysbiosisglycobiologyhuman genetic diseaseinflammatory bowel diseaseintestinal homeostasisintestinal stem cellsmucus barriershort-chain fatty acidssialylationST6GalNAc1
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