Evidence map›Paper›PMID 35303154›Full record

ArticleBiological cybernetics2022

Pulse-frequency-dependent resonance in a population of pyramidal neuron models.

Ryosuke Mori, Hiroyuki Mino, Dominique M Durand

Abstract read
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In one paragraph

Article in Biological cybernetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryosuke MoriDepartment of Engineering, Graduate School of Engineering, Kanto Gakuin University, 1-50-1 Mutsuura E., Kanazawa-ku, Yokohama, 236-8501, Japan.
Hiroyuki MinoDepartment of Engineering, Graduate School of Engineering, Kanto Gakuin University, 1-50-1 Mutsuura E., Kanazawa-ku, Yokohama, 236-8501, Japan. mino@ieee.org.ORCID 0000-0002-9601-628X
Dominique M DurandDepartment of Biomedical Engineering, Neural Engineering Center, Case Western Reserve University, Cleveland, OH, 44106, USA.

Funding

Detection and Control of EpilepsyR01NS060757 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI DURAND, DOMINIQUE M · 2008 to 2016
$2.8M
6 · The paper itself

Abstract

Stochastic resonance is known as a phenomenon whereby information transmission of weak signal or subthreshold stimuli can be enhanced by additive random noise with a suitable intensity. Another phenomenon induced by applying deterministic pulsatile electric stimuli with a pulse frequency, commonly used for deep brain stimulation (DBS), was also shown to improve signal-to-noise ratio in neuron models. The objective of this study was to test the hypothesis that pulsatile high-frequency stimulation could improve the detection of both sub- and suprathreshold synaptic stimuli by tuning the frequency of the stimulation in a population of pyramidal neuron models. Computer simulations showed that mutual information estimated from a population of neural spike trains displayed a typical resonance curve with a peak value of the pulse frequency at 80-120 Hz, similar to those utilized for DBS in clinical situations. It is concluded that a "pulse-frequency-dependent resonance" (PFDR) can enhance information transmission over a broad range of synaptically connected networks. Since the resonance frequency matches that used clinically, PFDR could contribute to the mechanism of the therapeutic effect of DBS.

Indexed as

NeuronsPyramidal CellsAction PotentialsComputer SimulationModels, NeurologicalStochastic ProcessesDeep brain stimulationMutual informationNumerical methodStochastic resonance

Identifiers

PMID35303154

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.