Evidence map›Paper›PMID 35303112›Full record

ArticleAbdominal radiology (New York)2022

Conspicuity and muscle-invasiveness assessment for bladder cancer using VI-RADS: a multi-reader, contrast-free MRI study to determine optimal b-values for diffusion-weighted imaging.

Andrea Delli Pizzi, Domenico Mastrodicasa, Alessio Taraschi, Nicoletta Civitareale, Erica Mincuzzi, Stefano Censi, Michele Marchioni, Giulia Primiceri, Pietro Castellan, Roberto Castellucci and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Abdominal radiology (New York), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05783271 (Validity of Parametric MRI Using VIRAD Scoring in the Diagnosis of Cancer Bladder), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05783271 narecruitingnot on this mapstarted 2025, after this paper: background citation

Validity of Parametric MRI Using VIRAD Scoring in the Diagnosis of Cancer Bladder

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled58ConditionsBladder CancerArmsGadolinium
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea Delli PizziDepartment of Innovative Technologies in Medicine & Dentistry, "G. d'Annunzio" University, Chieti, Italy. andreadellipizzi@gmail.com.ORCID http://orcid.org/0000-0002-2011-3753
Domenico MastrodicasaDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Alessio TaraschiUnit of Radiology, "Santissima Annunziata" Hospital, Chieti, Italy.
Nicoletta CivitarealeUnit of Radiology, "Santissima Annunziata" Hospital, Chieti, Italy.
Erica MincuzziUnit of Radiology, "Santissima Annunziata" Hospital, Chieti, Italy.
Stefano CensiDepartment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University, Chieti, Italy.
Michele MarchioniDepartment of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS Annunziata Hospital, Chieti, Italy.
Giulia PrimiceriDepartment of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS Annunziata Hospital, Chieti, Italy.
Pietro CastellanDepartment of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS Annunziata Hospital, Chieti, Italy.
Roberto CastellucciDepartment of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS Annunziata Hospital, Chieti, Italy.
Giulio CoccoUnit of Ultrasound in Internal Medicine, Department of Medicine and Science of Aging, "G. D'Annunzio" University, Chieti, Italy.
Piero ChiacchiarettaCenter of Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Antonella ColasanteSurgical Pathology Unit, SS Annunziata Hospital, Chieti, Italy.
Antonio CorvinoMotor Science and Wellness Department, University of Naples "Parthenope", Naples, Italy.
Luigi SchipsDepartment of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University of Chieti, Urology Unit, SS Annunziata Hospital, Chieti, Italy.
Massimo CauloDepartment of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University, Chieti, Italy.

Funding

Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
6 · The paper itself

Abstract

objectiveTo (1) compare bladder cancer (BC) muscle invasiveness among three b-values using a contrast-free approach based on Vesical Imaging-Reporting and Data System (VI-RADS), to (2) determine if muscle-invasiveness assessment is affected by the reader experience, and to (3) compare BC conspicuity among three b-values, qualitatively and quantitatively.

methodsThirty-eight patients who underwent a bladder MRI on a 3.0-T scanner were enrolled. The gold standard was histopathology report following transurethral resection of BC. Three sets of images, including T2w and different b-values for DWI, set 1 (b = 1000 s/mm

resultsAUCs of muscle-invasiveness assessment ranged from 0.896 to 0.984 (reader 1), 0.952-0.968 (reader 2), and 0.952-0.984 (reader 3) without significant differences among different sets and readers (p > 0.05). The mean conspicuity qualitative scores were higher in Set 1 (2.21-2.33), followed by Set 2 (2-2.16) and Set 3 (1.82-2.14). The quantitative conspicuity assessment showed that mean normalized intensity of tumor was significantly higher in Set 2 (4.217-4.737) than in Set 1 (3.923-4.492) and Set 3 (3.833-3.992) (p < 0.05).

conclusionMuscle invasiveness can be assessed with high accuracy using a contrast-free protocol with T2W and DWI, regardless of reader's experience. b = 1500 s/mm

Indexed as

Urinary BladderUrinary Bladder NeoplasmsDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleMusclesBladder cancerDiffusion-weighted imagingMRIVI-RADS

Identifiers

PMID35303112
PMCPMC9038787

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.