Evidence map›Paper›PMID 35303021›Full record

ArticlePloS one2022

Nanoencapsulation of buriti oil (Mauritia flexuosa L.f.) in porcine gelatin enhances the antioxidant potential and improves the effect on the antibiotic activity modulation.

Neyna de Santos Morais, Thaís Souza Passos, Gabriela Rocha Ramos, Victoria Azevedo Freire Ferreira, Susana Margarida Gomes Moreira, Gildácio Pereira Chaves Filho, Ana Paula Gomes Barreto, Pedro Ivo Palacio Leite, Ray Silva de Almeida, Cícera Laura Roque Paulo and 5 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Antioxidant and Lipid-Lowering Effects of Buriti Oil (Molecules (Basel, Switzerland) · 2023
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Neyna de Santos MoraisNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Thaís Souza PassosDepartment of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Gabriela Rocha RamosDepartment of Pharmacy, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Victoria Azevedo Freire FerreiraDepartment of Pharmacy, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Susana Margarida Gomes MoreiraDepartment of Cellular and Molecular Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Gildácio Pereira Chaves FilhoDepartment of Cellular and Molecular Biology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Ana Paula Gomes BarretoDepartment of Pharmacy, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Pedro Ivo Palacio LeiteDepartment of Chemical Biology, Regional University of Cariri, Crato, CE, Brasil.
Ray Silva de AlmeidaDepartment of Chemical Biology, Regional University of Cariri, Crato, CE, Brasil.
Cícera Laura Roque PauloDepartment of Chemical Biology, Regional University of Cariri, Crato, CE, Brasil.
Rafael FernandesChemical Intitute, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID 0000-0001-6797-9119
Sebastião Ânderson Dantas da SilvaNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID 0000-0003-1795-4620
Sara Sayonara da Cruz NascimentoPostgraduate Program in Biotechnology-RENORBIO, Biosciences Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID 0000-0002-9419-9027
Francisco Canindé de Sousa JúniorNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID 0000-0003-2042-4348
Cristiane Fernandes de AssisNutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID 0000-0001-7595-5395
Universidade Federal do Rio Grande do Norte · BRUniversidade Regional do Cariri · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study evaluated the cytotoxicity, antioxidant potential, and antimicrobial effect on the antibiotic activity modulation of gelatin nanoparticles containing buriti oil (OPG). The cytotoxicity analysis was performed on Chinese Hamster Ovary Cells (CHO) using a MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test. The antioxidant potential of buriti oil and OPG was determined by total antioxidant capacity, reducing power, and the ABTS (2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) test. The modulating antimicrobial activity was evaluated by determining the minimum inhibitory concentration (MIC) concentration against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, gentamicin and norflaxacillin. The nanoformulation of OPG did not show a cytotoxic effect on CHO cells and had a higher antioxidant potential than free buriti oil (p<0.05). The combination of antibiotics with free buriti oil and OPG was more efficient in inhibiting E. coli and P. aeruginosa than isolated norfloxacillin and gentamicin (p<0.05). Regarding the inhibition of S. aureus, OPG in combination with norfloxacillin reduced MIC by 50%. Nanoencapsulation was a viable alternative to enhance functionality and adding commercial value to buriti oil.

Indexed as

AntioxidantsArecaceaeAnimalsAnti-Bacterial AgentsCarotenoidsCHO CellsCricetinaeCricetulusEscherichia coliGelatinGentamicinsMicrobial Sensitivity TestsPlant OilsStaphylococcus aureusSwineAnti-Bacterial AgentsAntioxidantsburiti oilCarotenoidsGelatinGentamicinsPlant Oils

Identifiers

PMID35303021
PMCPMC8932573
OpenAlexW4220866394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.