Evidence map›Paper›PMID 35302909›Full record

Trial reportHuman vaccines & immunotherapeutics2022

Human Papillomavirus vaccination clinical decision support for young adults in an upper midwestern healthcare system: a clinic cluster-randomized control trial.

Melissa L Harry, Stephen E Asche, Laura A Freitag, JoAnn M Sperl-Hillen, Daniel M Saman, Heidi L Ekstrom, Ella A Chrenka, Anjali R Truitt, Clayton I Allen, Patrick J O'Connor and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02986230 (Implementing Cancer Prevention Using Patient-Provider Clinical Decision Support), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02986230 nacompletednot on this map

Implementing Cancer Prevention Using Patient-Provider Clinical Decision Support

TypeinterventionalSponsorHealthPartners InstituteRan2018 to 2021Enrolled35,953ConditionsCancer PreventionArmsCP-CDS
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Melissa L HarryEssentia Institute of Rural Health, Duluth, MN, USA.ORCID 0000-0003-2016-4398
Stephen E AscheHealthPartners Institute, Bloomington, MN, USA.
Laura A FreitagEssentia Institute of Rural Health, Duluth, MN, USA.
JoAnn M Sperl-HillenHealthPartners Institute, Bloomington, MN, USA.
Daniel M SamanEssentia Institute of Rural Health, Duluth, MN, USA.
Heidi L EkstromHealthPartners Institute, Bloomington, MN, USA.
Ella A ChrenkaHealthPartners Institute, Bloomington, MN, USA.
Anjali R TruittHealthPartners Institute, Bloomington, MN, USA.
Clayton I AllenEssentia Institute of Rural Health, Duluth, MN, USA.
Patrick J O'ConnorHealthPartners Institute, Bloomington, MN, USA.
Steven P DehmerHealthPartners Institute, Bloomington, MN, USA.
Joseph A BiancoEssentia Health - Ely Clinic, Ely, MN, USA.
Thomas E ElliottHealthPartners Institute, Bloomington, MN, USA.
HealthPartners · USEssentia Health · US

Funding

Implementing Cancer Prevention Using Patient - Provider Clinical Decision SupportR01CA193396 · NCI · HEALTHPARTNERS INSTITUTE · PI ELLIOTT, THOMAS EDWARD · 2016 to 2020
$3.0M
NCI NIH HHS R01 CA193396
6 · The paper itself

Abstract

introductionHuman papillomavirus (HPV) vaccination rates are low in young adults. Clinical decision support (CDS) in primary care may increase HPV vaccination. We tested the treatment effect of algorithm-driven, web-based, and electronic health record-linked CDS with or without shared decision-making tools (SDMT) on HPV vaccination rates compared to usual care (UC).

methodsIn a clinic cluster-randomized control trial conducted in a healthcare system serving a largely rural population, we randomized 34 primary care clinic clusters (with three clinics sharing clinicians randomized together) to: CDS; CDS+SDMT; UC. The sample included young adults aged 18-26 due for HPV vaccination with a study index visit from 08/01/2018-03/15/2019 in a study clinic. Generalized linear mixed models tested differences in HPV vaccination status 12 months after index visits by study arm.

resultsAmong 10,253 patients, 6,876 (65.2%) were due for HPV vaccination, and 5,054 met study eligibility criteria. In adjusted analyses, the HPV vaccination series was completed by 12 months in 2.3% (95% CI: 1.6%-3.2%) of CDS, 1.6% (95% CI: 1.1%-2.3%) of CDS+SDMT, and 2.2% (95% CI: 1.6%-3.0%) of UC patients, and at least one HPV vaccine was received by 12 months in 13.1% (95% CI: 10.6%-16.1%) of CDS, 9.2% (95% CI: 7.3%-11.6%) of CDS+SDMT, and 11.2% (95% CI: 9.1%-13.7%) of UC patients. Differences were not significant between arms. Females, those with prior HPV vaccinations, and those seen at urban clinics had significantly higher odds of HPV vaccination in adjusted models. DISCUSSION: CDS may require optimization for young adults to significantly impact HPV vaccination.

trial registrationclinicaltrials.gov NCT02986230, 12/6/2016.

Indexed as

AlphapapillomavirusDecision Support Systems, ClinicalPapillomavirus InfectionsPapillomavirus VaccinesDelivery of Health CareFemaleHumansPrimary Health CareVaccinationYoung AdultPapillomavirus VaccinesClinical decision supportcluster randomized control trialhuman papillomavirus vaccinationprimary cancer preventionprimary careshared decision makingyoung adults

Identifiers

PMID35302909
PMCPMC9009937
OpenAlexW4220898828

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.