Evidence map›Paper›PMID 35302662›Full record

ArticleAllergy2022

Pollen exposure is associated with risk of respiratory symptoms during the first year of life.

Amanda Gisler, Marloes Eeftens, Kees de Hoogh, Danielle Vienneau, Yasmin Salem, Sophie Yammine, Julian Jakob, Olga Gorlanova, Fabienne Decrue, Regula Gehrig and 5 more

Abstract read
In one paragraph

Article in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Symptom probability increases at low pollen exposure in adolescents with allergic rhinitis findings from the GINIplus and LISA birth cohorts.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Amanda GislerUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0002-9708-1200
Marloes EeftensSwiss Tropical and Public Health Institute Basel, Basel, Switzerland.ORCID 0000-0002-1002-3412
Kees de HooghSwiss Tropical and Public Health Institute Basel, Basel, Switzerland.ORCID 0000-0001-5974-2007
Danielle VienneauSwiss Tropical and Public Health Institute Basel, Basel, Switzerland.ORCID 0000-0002-6309-6439
Yasmin SalemUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0001-8731-0885
Sophie YammineUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0001-7720-3445
Julian JakobDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-8429-3231
Olga GorlanovaUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0002-3153-7404
Fabienne DecrueUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0003-3005-3018
Regula GehrigFederal Office of Meteorology and Climatology MeteoSwiss, Zurich, Switzerland.ORCID 0000-0002-8223-9482
Urs FreyUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0003-3773-2822
Philipp LatzinUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0002-5239-1571
Oliver FuchsUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0002-7127-5226
Jakob UsemannUniversity Children's Hospital Basel (UKBB), Basel, Switzerland.ORCID 0000-0002-9987-2866
BILD study group

Funding

Swiss National Science Foundation 320300_204717
6 · The paper itself

Abstract

backgroundPollen exposure is associated with respiratory symptoms in children and adults. However, the association of pollen exposure with respiratory symptoms during infancy, a particularly vulnerable period, remains unclear. We examined whether pollen exposure is associated with respiratory symptoms in infants and whether maternal atopy, infant's sex or air pollution modifies this association.

methodsWe investigated 14,874 observations from 401 healthy infants of a prospective birth cohort. The association between pollen exposure and respiratory symptoms, assessed in weekly telephone interviews, was evaluated using generalized additive mixed models (GAMMs). Effect modification by maternal atopy, infant's sex, and air pollution (NO

resultsPer infant, 37 ± 2 (mean ± SD) respiratory symptom scores were assessed during the analysis period (January through September). Pollen exposure was associated with increased respiratory symptoms during the daytime (RR [95% CI] per 10% pollen/m

conclusionEven as early as during the first year of life, pollen exposure was associated with an increased risk of respiratory symptoms, independent of maternal atopy and infant's sex. Because infancy is a particularly vulnerable period for lung development, the identified adverse effect of pollen exposure may be relevant for the evolvement of chronic childhood asthma.

Indexed as

Air PollutionAsthmaAdultChildHumansInfantParticulate MatterPollenProspective StudiesParticulate Matteraeroallergencohort studyinfancyinteractionlongitudinal study

Identifiers

PMID35302662
PMCPMC10078730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.