Evidence map›Paper›PMID 35302385›Full record

ReviewCephalalgia : an international journal of headache2022

The spectrum of indomethacin-responsive headaches in children and adolescents.

Kenneth A Myers, Rebecca Barmherzig, Nichelle R Raj, Saoussen Berrahmoune, Pablo Ingelmo, Christine Saint-Martin, Afsheen Q Khan, Megan Kouri, Cynthia Morris, Andrew D Hershey and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cephalalgia : an international journal of headache, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kenneth A MyersResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-7831-4593
Rebecca BarmherzigDepartment of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Nichelle R RajDepartment of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Saoussen BerrahmouneResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Pablo IngelmoDepartment of Pediatric Anesthesiology, McGill University Health Center, Montreal, Quebec, Canada.
Christine Saint-MartinDepartment of Radiology, McGill University Health Center, Montreal, Quebec, Canada.
Afsheen Q KhanResearch Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Megan KouriFaculty of Medicine, McGill University, Montreal, Quebec, Canada.
Cynthia MorrisChild and Adolescent Headache Program, University of California San Francisco, San Francisco, CA, USA.
Andrew D HersheyDepartments of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joanne KacperskiDepartments of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Marielle A KabboucheDepartments of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Nada MohamedDepartment of Pediatric Anesthesiology, McGill University Health Center, Montreal, Quebec, Canada.
Rashmi R RaoDepartment of Neurology, Louisiana State University Health Sciences Center and Children's Hospital New Orleans, New Orleans, LA, USA.
Ana Marissa Lagman-BartolomeDivision of Neurology, Hospital for Sick Children and Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
Amy A GelfandChild and Adolescent Headache Program, University of California San Francisco, San Francisco, CA, USA.
Christina L SzperkaDepartment of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4786-8889
Serena L OrrDivision of Neurology, Department of Pediatrics, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Funding

Occipital Nerve Blocks for Acute Treatment of Pediatric MigraineK23NS102521 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SZPERKA, CHRISTINA LYNCH · 2018 to 2022
$940k
NINDS NIH HHS K23 NS102521
6 · The paper itself

Abstract

backgroundHeadaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied.

methodsWe reviewed pediatric patients with headache showing ≥80% improvement with indomethacin, from seven academic medical centers.

resultsWe included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2-16 y). Headache syndromes included hemicrania continua (n = 13), paroxysmal hemicrania (n = 10), primary stabbing headache (n = 2), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n = 1), primary exercise headache (n = 1) and primary cough headache (n = 1). Adverse events were reported in 13, most commonly gastrointestinal symptoms, which often improved with co-administration of gastro-protective agents.

conclusionIndomethacin-responsive headaches occur in children and adolescents, and include headache syndromes, such as primary cough headache, previously thought to present only in adulthood. The incidence of adverse events is high, and patients must be co-treated with a gastroprotective agent.

Indexed as

NeuralgiaParoxysmal HemicraniaAdolescentAdultChildFemaleHeadacheHumansIndomethacinTearsIndomethacinhemicrania continuaIndomethacinparoxysmal hemicraniaprimary cough headache

Identifiers

PMID35302385
PMCPMC9218410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.