Evidence map›Paper›PMID 35301805›Full record

ArticleGenes, brain, and behavior2022

Sex differences in GABA

Madeline K Ashton, André V L Rueda, Ada M-C Ho, Noradibah Arina Binte M Noor Aizin, Hansa Sharma, Peter R Dodd, Alfreda Stadlin, Rosana Camarini

Open access · hybridAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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  9. Sex differences in GABAGenes, brain, and behavior · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Madeline K AshtonSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
André V L RuedaSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-4581-8992
Ada M-C HoSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-4989-8782
Noradibah Arina Binte M Noor AizinSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Hansa SharmaSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Peter R DoddSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-5970-0181
Alfreda StadlinCollege of Medicine, Ajman University, Ajman, UAE.ORCID 0000-0002-7231-5832
Rosana CamariniDepartamento de Farmacologia, ICB, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-8131-6108
The University of Queensland · AUAjman University · AEMayo Clinic · USUniversidade de São Paulo · BR

Funding

GENE EXPRESSION IN THE HUMAN ALCOHOLIC BRAINR01AA012404 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI MAYFIELD, ROY DAYNE · 2000 to 2025
$10.7M
Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R01 AA012404NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

Male and female human subjects show contrasting propensities to misuse drugs of addiction, including alcohol. These differences lead to different psychological and neurological consequences, such as the likelihood of developing dependence. The pattern and extent of brain damage in alcohol-use disorder cases also varies with comorbid disease. To explore mechanisms that might underlie these outcomes, we used autopsy tissue to determine mRNA transcript expression in relation to genotype for two GABA

Indexed as

AlcoholismReceptors, GABA-AFemaleGenotypeHumansLiver CirrhosisMalePolymorphism, Single NucleotideSex CharacteristicsReceptors, GABA-Aalcohol misusegenotype-phenotype interactionshuman brainqRT-PCR

Identifiers

PMID35301805
PMCPMC9744570
OpenAlexW4220715369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.