Evidence map›Paper›PMID 35301623›Full record

Observational studyEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2022

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting.

Burcu Isler, Berna Özer, Güle Çınar, Abdullah Tarık Aslan, Cansel Vatansever, Caitlin Falconer, İştar Dolapçı, Funda Şimşek, Necla Tülek, Hamiyet Demirkaya and 23 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Emergence of carbapenem-resistant putative hypervirulentEmerging microbes & infections · 2026
    Article
  3. Rising antimicrobial resistance in urinary tract infections in Türkiye: an urgent need for update on regional treatment strategies and for enhanced antimicrobial stewardship efforts.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Genomic Characterization and Resistance Mechanisms of Carbapenem-ResistantInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Article
  17. Article
  18. Observational
  19. Emergence ofAntibiotics (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 14 institutions in 2 countries.

Burcu IslerCentre for Clinical Research, University of Queensland, Brisbane, Australia.
Berna ÖzerClinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
Güle ÇınarInfectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
Abdullah Tarık AslanInfectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
Cansel VatanseverClinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
Caitlin FalconerCentre for Clinical Research, University of Queensland, Brisbane, Australia.
İştar DolapçıClinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
Funda ŞimşekInfectious Diseases and Clinical Microbiology, University of Health Sciences, Ministry of Health Prof Dr Cemil Taşçıoğlu City Hospital, Istanbul, Turkey.
Necla TülekInfectious Diseases and Clinical Microbiology, Faculty of Medicine, Atilim University, Ankara, Turkey.
Hamiyet DemirkayaInfectious Diseases and Clinical Microbiology, Başkent University, Ankara Hospital, Ankara, Turkey.
Şirin MenekşeInfectious Diseases, Koşuyolu Kartal Heart Training and Research Hospital, Istanbul, Turkey.
Halis AkalinInfectious Diseases and Clinical Microbiology, Uludağ University School of Medicine, Bursa, Turkey.
İlker İnanç BalkanInfectious Diseases and Clinical Microbiology, School of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Mehtap AydınInfectious Diseases and Clinical Microbiology, Ümraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Elif Tükenmez TigenInfectious Diseases and Clinical Microbiology, Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey.
Safiye Koçulu DemirInfectious Diseases and Clinical Microbiology, Demiroglu Bilim University, Istanbul, Turkey.
Mahir KapmazInfectious Diseases and Clinical Microbiology, Koç University Hospital, Istanbul, Turkey.
Şiran KeskeInfectious Diseases, School of Medicine, Koç University, Rumelifeneri, 34450, Sarıyer, Istanbul, Turkey.
Özlem DoğanClinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
Çiğdem ArabacıClinical Microbiology, University of Health Sciences, Ministry of Health Prof Dr Cemil Taşçıoğlu City Hospital, Istanbul, Turkey.
Serap YağcıClinical Microbiology, Ankara Training and Research Hospital, Ankara, Turkey.
Gülşen HazırolanClinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
Veli Oğuzalp BakırGraduate School of Sciences and Engineering, Koç University, Istanbul, Turkey.
Mehmet GönenIndustrial Engineering, College of Engineering, Koç University, Istanbul, Turkey.
Mark D ChatfieldCentre for Clinical Research, University of Queensland, Brisbane, Australia.
Brian FordeCentre for Clinical Research, University of Queensland, Brisbane, Australia.
Neşe SaltoğluInfectious Diseases and Clinical Microbiology, School of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Alpay AzapInfectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Turkey.
Özlem AzapInfectious Diseases and Clinical Microbiology, Başkent University, Ankara Hospital, Ankara, Turkey.
Murat AkovaInfectious Diseases and Clinical Microbiology, Hacettepe University School of Medicine, Ankara, Turkey.
David L PatersonCentre for Clinical Research, University of Queensland, Brisbane, Australia.
Füsun CanClinical Microbiology, School of Medicine, Koç University, Istanbul, Turkey.
Önder ErgönülInfectious Diseases, School of Medicine, Koç University, Rumelifeneri, 34450, Sarıyer, Istanbul, Turkey. oergonul@ku.edu.tr.
Koç University · TRUniversity of Queensland · AUAnkara University · TRHacettepe University · TRBaşkent University Hospital · TRIstanbul University · TRMinistry of Health · TRAtilim University · TRBursa Uludağ Üni̇versi̇tesi̇ · TRIstanbul Bilim University · TRKartal Koşuyolu High Specialization Training and Research Hospital · TRMarmara University · TRSağlık Bilimleri Üniversitesi · TRÜmraniye Eğitim ve Araştırma Hastanesi · TR

Funding

Pfizer Foundation 56644459
6 · The paper itself

Abstract

A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.

Indexed as

Klebsiella InfectionsSepsisAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsProspective StudiesAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsCeftazidime-avibactamKlebsiella pneumoniaeOXA-232OXA-48ST2096

Identifiers

PMID35301623
OpenAlexW4220921377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.