Evidence map›Paper›PMID 35301622›Full record

ReviewJournal of assisted reproduction and genetics2022

Epigenetics of pregnancy: looking beyond the DNA code.

Daniela Zuccarello, Ugo Sorrentino, Valeria Brasson, Loris Marin, Chiara Piccolo, Antonio Capalbo, Alessandra Andrisani, Matteo Cassina

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  6. Experiences of Discrimination and DNA Methylation Among Black Nulliparous Women.Journal of racial and ethnic health disparities · 2026
    Article
  7. Article
  8. The Correlation betweenInternational journal of fertility & sterility · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniela Zuccarello *Clinical Genetics Unit, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy. daniela.zuccarello@unipd.it.ORCID http://orcid.org/0000-0001-5826-6715
Ugo Sorrentino *Clinical Genetics Unit, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
Valeria BrassonClinical Genetics Unit, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
Loris MarinGynaecological Clinic, Department of Women's and Children's Health, University of Padua, Padua, Italy.
Chiara PiccoloClinical Genetics Unit, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
Antonio CapalboIgenomix Italy, Marostica, VI, Italy.
Alessandra AndrisaniGynaecological Clinic, Department of Women's and Children's Health, University of Padua, Padua, Italy.
Matteo CassinaClinical Genetics Unit, Department of Women's and Children's Health, University Hospital of Padova, Padua, Italy.
University of Padua · ITIgenomix · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetics is the branch of genetics that studies the different mechanisms that influence gene expression without direct modification of the DNA sequence. An ever-increasing amount of evidence suggests that such regulatory processes may play a pivotal role both in the initiation of pregnancy and in the later processes of embryonic and fetal development, thus determining long-term effects even in adult life. In this narrative review, we summarize the current knowledge on the role of epigenetics in pregnancy, from its most studied and well-known mechanisms to the new frontiers of epigenetic regulation, such as the role of ncRNAs and the effects of the gestational environment on fetal brain development. Epigenetic mechanisms in pregnancy are a dynamic phenomenon that responds both to maternal-fetal and environmental factors, which can influence and modify the embryo-fetal development during the various gestational phases. Therefore, we also recapitulate the effects of the most notable environmental factors that can affect pregnancy and prenatal development, such as maternal nutrition, stress hormones, microbiome, and teratogens, focusing on their ability to cause epigenetic modifications in the gestational environment and ultimately in the fetus. Despite the promising advancements in the knowledge of epigenetics in pregnancy, more experience and data on this topic are still needed. A better understanding of epigenetic regulation in pregnancy could in fact prove valuable towards a better management of both physiological pregnancies and assisted reproduction treatments, other than allowing to better comprehend the origin of multifactorial pathological conditions such as neurodevelopmental disorders.

Indexed as

Epigenesis, GeneticFetal DevelopmentAdultDNAFemaleFetusHumansPregnancyDNABrain developmentEmbryo and fetus developmentEpigeneticsmiRNAPregnancyReview

Identifiers

PMID35301622
PMCPMC9050975
OpenAlexW4220891411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.