ArticleCancer immunology, immunotherapy : CII2022
Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer.
Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
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- Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients.Journal of translational medicine · 2024Article
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- Microbiota composition and its impact on DNA methylation in colorectal cancer.Frontiers in genetics · 2023Review
- Tumour Colonisation ofCancers · 2022Article
- Effects of gut microbiota on immune responses and immunotherapy in colorectal cancer.Frontiers in immunology · 2022Review
- Systematic review and meta-analysis of oral squamous cell carcinoma associated oral microbiome.Frontiers in microbiology · 2022Article
- Biofilms and core pathogens shape the tumor microenvironment and immune phenotype in colorectal cancer.Gut microbesArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The importance of the tumour microbiome in different aspects of colorectal cancer (CRC) has been increasingly recognised, but many questions remain. The aim of this study was to explore the effect of specific CRC associated microbes on the tumour immune response, which has a considerable prognostic value in CRC. We applied specific qPCR to detect Parvimonas micra and Fusobacterium nucleatum in tumour tissues from an immunologically well-characterised cohort of 69 CRC patients. This cohort included detailed analyses of immune profiles based on flow cytometry and transcriptomics in tumour tissue and blood, along with comprehensive analyses of molecular subtypes. P. micra and F. nucleatum were detected in 24% and 64% of tumour tissues, respectively. We found a significant association of P. micra with high-grade tumours and tumours of CMS1 subtype. F. nucleatum was significantly associated with right-sided tumours, microsatellite instability, and CMS1 tumours. The immunological analyses revealed significant associations of P. micra with activated CD69
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