Evidence map›Paper›PMID 35301555›Full record

ArticleInternational journal of colorectal disease2022

Increased standardised incidence ratio of cardiovascular diseases among colorectal cancer patients.

Hsin-Yin Hsu, Yih-Jong Chern, Cheng-Tzu Hsieh, Tzu-Lin Yeh, Ming-Chieh Tsai, Chia-Chun Wang, Bo-Yu Hsiao, Jing-Rong Jhuang, Chun-Ju Chiang, Wen-Chung Lee and 1 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Trends in ischemic heart disease mortality among older adults with co-existing colorectal cancer in the US (1999-2023): a 25-Year retrospective study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Article
  5. The Risk of Type 2 Diabetes among Older Asian, Native Hawaiian, and Pacific Islander Colorectal Cancer Survivors: A Population-Based Study Using the SEER-Medicare Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hsin-Yin HsuDepartment of Family Medicine, Taipei MacKay Memorial Hospital, Taipei, Taiwan.
Yih-Jong ChernDivision of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, TaoYuan, Taiwan.
Cheng-Tzu HsiehInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Tzu-Lin YehInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ming-Chieh TsaiDepartment of Medicine, MacKay Medical College, New Taipei City, Taiwan.
Chia-Chun WangDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Bo-Yu HsiaoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Jing-Rong JhuangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Chun-Ju ChiangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Wen-Chung LeeInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Kuo-Liong ChienInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. klchien@ntu.edu.tw.ORCID http://orcid.org/0000-0003-4979-8351
National Taiwan University · TWChang Gung Memorial Hospital · TWMackay Memorial Hospital · TWNational Taiwan University Hospital · TW

Funding

Health Promotion Administration, Ministry of Health and Welfare A1091115
6 · The paper itself

Abstract

purposeEvidence regarding the relationship between colorectal cancer and the risk of cardiovascular disease (CVD) is limited. Thus, in this study, we aimed to determine the standardised incidence ratio (SIR) of CVDs in colorectal cancer patients in Taiwan.

methodsA population-based cohort study enrolling the incident colorectal cancer population based on the Cancer Registry Database from 2007 to 2016 was conducted (n = 94,233, mean age: 62.4 years, 43.0% women). New cases of CVD, including coronary heart disease and ischemic stroke, through 31 December 2018 were obtained from the National Health Insurance Research Database and National Death Registry. Compared with the general population (n = 1,977,659, mean age: 44.3 years, 49.6% women), age- and sex-specific SIRs for CVDs were calculated by the time since diagnosis.

resultsA total of 6852 cardiovascular events occurred in colorectal cancer patients during a median follow-up of 4.4 years. The SIR of CVD was highest in the first year after diagnosis (SIR: 1.45, 95% confidence interval: 1.39-1.50); however, this decreased to the same value as that of the general population in later years. Similar patterns were observed for the SIR of coronary heart disease. However, the SIR of ischemic stroke among colorectal cancer patients was low from the second year following cancer diagnosis.

conclusionsColorectal cancer patients are at an increased risk of developing CVD, especially coronary heart disease, during the first 3 years following colorectal cancer diagnosis.

Indexed as

Cardiovascular DiseasesColorectal NeoplasmsAdultCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRisk FactorsCardio-oncologyCardiovascular diseasesColorectal cancer

Identifiers

PMID35301555
PMCPMC8976771
OpenAlexW4220655956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.