Evidence map›Paper›PMID 35301532›Full record

ArticleInternational journal of epidemiology2022

Association between indoor residual spraying and pregnancy outcomes: a quasi-experimental study from Uganda.

Michelle E Roh, Arthur Mpimbaza, Brenda Oundo, Amanda Irish, Maxwell Murphy, Sean L Wu, Justin S White, Stephen Shiboski, M Maria Glymour, Roly Gosling and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Michelle E RohDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID 0000-0002-6268-0801
Arthur MpimbazaChild Health and Development Centre, Makerere University, College of Health Sciences, Kampala, Uganda.
Brenda OundoInfectious Diseases Research Collaboration, Kampala, Uganda.
Amanda IrishDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Maxwell MurphyDepartment of Biostatistics, University of California, Berkeley, CA, USA.
Sean L WuDepartment of Biostatistics, University of California, Berkeley, CA, USA.
Justin S WhiteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID 0000-0002-3388-9569
Stephen ShiboskiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Roly GoslingDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Grant DorseyDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
Hugh SturrockDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of California, Berkeley · USInfectious Diseases Research Collaboration · UGLee University · USMakerere University · UG

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
The impact of vector control interventions on adverse birth outcomes.F31HD096861 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROH, MICHELLE · 2018 to 2020
$99k
National Institutes of Health, University of California, San Francisco-Gladstone Institute of Virology & Immunology Center for AIDS Research P30-AI027763NIAID NIH HHS P30 AI027763NICHD NIH HHS F31 HD096861
6 · The paper itself

Abstract

backgroundMalaria is a risk factor for adverse pregnancy outcomes. Indoor residual spraying with insecticide (IRS) reduces malaria infections, yet the effects of IRS on pregnancy outcomes are not well established. We evaluated the impact of a large-scale IRS campaign on pregnancy outcomes in Eastern Uganda.

methodsBirth records (n = 59 992) were obtained from routine surveillance data at 25 health facilities from five districts that were part of the IRS campaign and six neighbouring control districts ∼27 months before and ∼24 months after the start of the campaign (January 2013-May 2017). Campaign effects on low birthweight (LBW) and stillbirth incidence were estimated using the matrix completion method (MC-NNM), a machine-learning approach to estimating potential outcomes, and compared with the difference-in-differences (DiD) estimator. Subgroup analyses were conducted by HIV and gravidity.

resultsMC-NNM estimates indicated that the campaign was associated with a 33% reduction in LBW incidence: incidence rate ratio (IRR) = 0.67 [95% confidence interval (CI): 0.49-0.93)]. DiD estimates were similar to MC-NNM [IRR = 0.69 (0.47-1.01)], despite a parallel trends violation during the pre-IRS period. The campaign was not associated with substantial reductions in stillbirth incidence [IRRMC-NNM = 0.94 (0.50-1.77)]. HIV status modified the effects of the IRS campaign on LBW [βIRSxHIV = 0.42 (0.05-0.78)], whereby HIV-negative women appeared to benefit from the campaign [IRR = 0.70 (0.61-0.81)], but not HIV-positive women [IRR = 1.12 (0.59-2.12)].

conclusionsOur results support the effectiveness of the campaign in Eastern Uganda based on its benefit to LBW prevention, though HIV-positive women may require additional interventions. The IRS campaign was not associated with a substantively lower stillbirth incidence, warranting further research.

Indexed as

InsecticidesMalariaDisease ProgressionFemaleHumansMosquito ControlPregnancyStillbirthUgandaInsecticidesadverse pregnancy outcomesdifference-in-differencesindoor residual sprayinglow birthweightMalaria in pregnancymatrix completion methodPlasmodium falciparumstillbirth

Identifiers

PMID35301532
PMCPMC9557839
OpenAlexW4214751214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.