Evidence map›Paper›PMID 35301333›Full record

ArticleNature communications2022

Autophagy impairment in liver CD11c

Lauriane Galle-Treger, Doumet Georges Helou, Christine Quach, Emily Howard, Benjamin P Hurrell, German R Aleman Muench, Pedram Shafiei-Jahani, Jacob D Painter, Andrea Iorga, Lily Dara and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Enhancing autophagy in CD11cCell reports · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Lauriane Galle-Treger *Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Doumet Georges Helou *Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5835-9214
Christine QuachDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4802-8013
Emily HowardDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Benjamin P HurrellDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
German R Aleman MuenchJanssen Research and Development, San Diego, CA, USA.
Pedram Shafiei-JahaniDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jacob D PainterDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrea IorgaDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lily DaraDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Juliet EmamaulleeDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4238-3057
Lucy Golden-MasonDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2087-4405
Hugo R RosenDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Pejman SorooshJanssen Research and Development, San Diego, CA, USA.
Omid AkbariDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. akbari@usc.edu.ORCID http://orcid.org/0000-0002-4359-9725
University of Southern California · USJanssen (United States) · US

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAPLOWITZ, NEIL · 1995 to 2020
$21.8M
INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMAR01ES021801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2012 to 2016
$3.9M
Study the link of autophagy dysfunction to allergic and neutrophilic asthma onsetR01HL151493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2020 to 2024
$3.6M
Maternal effect on offspring immunity against hepatitis B virusR01AI145813 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, OU, J.-H. JAMES · 2019 to 2023
$3.2M
Role of TNF receptor 2 on Pulmonary Group 2 Innate Lymphoid CellsR01HL159804 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2022 to 2025
$3.0M
Genetic and Environmental Determinants of Asthma EndophenotypesR01ES025786 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2015 to 2019
$2.8M
Induction of cells and pathways that promote respiratory tolerance in allergic asthmaR01HL144790 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2019 to 2022
$2.6M
E-Cigarette Vaping during Pregnancy and Lactation, Germ Cell Epigenetic Memory, and Transgenerational AsthmaR01HL151769 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ALLARD, PATRICK, REHAN, VIRENDER K · 2020 to 2023
$2.3M
Human Group 2 Innate Lympohocyte Cell (ILC2) populations contribute to Hepatic FibrosisR01DK106491 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOLDEN, LUCY MARY · 2015 to 2019
$1.8M
Innate Immunity, Cholesterol, and NASH PathogenesisR01DK117004 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOLDEN, LUCY MARY · 2020 to 2023
$1.5M
NHLBI NIH HHS R01 HL144790NHLBI NIH HHS R01 HL151493NHLBI NIH HHS R01 HL151769NHLBI NIH HHS R01 HL159804NIAID NIH HHS R01 AI145813NIDDK NIH HHS P30 DK048522NIDDK NIH HHS R01 DK106491NIDDK NIH HHS R01 DK117004NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R01 ES025786
6 · The paper itself

Abstract

There has been a global increase in rates of obesity with a parallel epidemic of non-alcoholic fatty liver disease (NAFLD). Autophagy is an essential mechanism involved in the degradation of cellular material and has an important function in the maintenance of liver homeostasis. Here, we explore the effect of Autophagy-related 5 (Atg5) deficiency in liver CD11c

Indexed as

Insulin ResistanceNon-alcoholic Fatty Liver DiseaseAnimalsAutophagyDiet, High-FatInterleukin-23LiverMiceMice, Inbred C57BLInterleukin-23

Identifiers

PMID35301333
PMCPMC8931085
OpenAlexW4220831026

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.