Evidence map›Paper›PMID 35301323›Full record

ArticleNature communications2022

Structural basis for activation and gating of IP

Emily A Schmitz, Hirohide Takahashi, Erkan Karakas

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The role of IPPflugers Archiv : European journal of physiology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Conformational landscape and clustering of human type 2 IPbioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Rice phospholipase C4 enhances CaPlant communications · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. From IP3RPEP6 Inhibition of IPCellular and molecular life sciences : CMLS · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily A Schmitz *Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, 37232, USA.ORCID 0000-0002-5122-8991
Hirohide Takahashi *Department of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, 37232, USA.ORCID 0000-0002-2553-8806
Erkan KarakasDepartment of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, 37232, USA. erkan.karakas@vanderbilt.edu.ORCID 0000-0001-6552-3185
Vanderbilt University · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Structure and function of inositol triphosphate receptorsR01GM141251 · NIGMS · VANDERBILT UNIVERSITY · PI KARAKAS, ERKAN · 2021 to 2024
$1.4M
Network-Attached Biomedical Research Data Management SystemS10RR031634 · NCRR · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2011 to 2011
$600k
NCRR NIH HHS S10 RR031634NIDDK NIH HHS P30 DK020593NIGMS NIH HHS R01 GM141251NIGMS NIH HHS T32 GM008320
6 · The paper itself

Abstract

A pivotal component of the calcium (Ca

Indexed as

CalciumEndoplasmic ReticulumCalcium SignalingCryoelectron MicroscopyHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsSignal TransductionCalciumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate Receptors

Identifiers

PMID35301323
PMCPMC8930994
OpenAlexW4220675322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.