Evidence map›Paper›PMID 35301303›Full record

ArticleNature communications2022

Structure-guided unlocking of Na

Cameron L Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P Arthur, Claudio Ciferri and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  12. Article
  13. Article
  14. Cryo-EM structure of human voltage-gated sodium channel NaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. When is a hydrophobic gate not a hydrophobic gate?The Journal of general physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Cameron L Noland *Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Han Chow Chua *Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark.ORCID 0000-0003-4477-174X
Marc Kschonsak *Department of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Stephanie Andrea HeusserDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark.ORCID 0000-0003-3224-4547
Nina BraunDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark.
Timothy ChangDepartment of BioMolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA.
Christine TamDepartment of BioMolecular Resources, Genentech Inc., South San Francisco, CA, 94080, USA.
Jia TangDepartment of Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, 94080, USA.
Christopher P ArthurDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA.
Claudio CiferriDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. ciferri.claudio@gene.com.ORCID 0000-0002-0804-2411
Stephan Alexander PlessDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DK 2100, Denmark. stephan.pless@sund.ku.dk.ORCID 0000-0001-6654-114X
Jian PayandehDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, 94080, USA. jpayandeh@interlinetx.com.ORCID 0000-0002-4015-9716
University of Copenhagen · DKGene Therapy Laboratory · FRInterScience (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlike classical voltage-gated sodium (Na

Indexed as

CalciumSodiumCationsHumansTetrodotoxinCalciumCationsSodiumTetrodotoxin

Identifiers

PMID35301303
PMCPMC8931054
OpenAlexW4221100231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.