Evidence map›Paper›PMID 35301269›Full record

ArticleJournal of obesity & metabolic syndrome2022

Mouse Model of Small for Gestational Age Offspring with Catch-up Growth Failure and Dysregulated Glucose Metabolism in Adulthood.

Hyeon Seok Moon, Hanbin Kim, Bohye Kim, Min-Seon Kim, Jae Hyun Kim, Obin Kwon

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of obesity & metabolic syndrome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hyeon Seok MoonDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Hanbin KimDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Bohye KimDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Min-Seon KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae Hyun KimDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-0203-7443
Obin KwonDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3702-7202
Seoul National University · KRSeoul National University Bundang Hospital · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to build mouse models of small for gestational age (SGA), recapitulating failure of catch-up growth and dysregulated metabolic outcomes in adulthood. Methods: Pregnant C57BL/6 mice were given a protein-restricted diet (PRD; 6% kcal from protein) during pregnancy without (model 1) or with cross-fostering (model 2). Model 3 extended the PRD to the end of the lactation period. Model 4 changed to a 9% PRD without cross-fostering. Results: Model 1 yielded a reduced size of offspring with a poor survival rate. Model 2 improved survival but offspring showed early catch-up growth. Model 3 maintained a reduced size of offspring after weaning with a higher body mass index and blood glucose levels in adult stages. Model 4 increased the survival of the offspring while maintaining a reduced size and dysregulated glucose metabolism. Conclusion: Models 3 and 4 are suitable for studying SGA accompanying adulthood short stature and metabolic disorders.

Indexed as

Glucose metabolism disordersGrowth failureObesitySmall for gestational age

Identifiers

PMID35301269
PMCPMC8987454
OpenAlexW4221072966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.