Evidence map›Paper›PMID 35301266›Full record

ArticleRMD open2022

Impact of disease activity outcome measures reporting in the medical records of patients with axial spondyloarthritis on the retention rates of biological treatment: the example of secukinumab use in daily practice in France.

Maxime Dougados, Julien Lucas, Emilie Desfleurs, Cédric Lukas, Alain Saraux, Anne Tournadre, Adeline Ruyssen-Witrand, Daniel Wendling, Philippe Goupille, Pascal Claudepierre

Abstract readMulticenter Study
In one paragraph

Article in RMD open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maxime DougadosHopital Cochin, Rheumatology, University of Paris, Paris, France maxime.dougados@aphp.fr.ORCID 0000-0003-3009-6229
Julien LucasBiostatistics, RCTs, Lyon, France.
Emilie DesfleursMedical affairs, Novartis Pharma SAS, Rueil-Malmaison, France.
Cédric LukasRhumatologie, University of Montpellier, Montpellier, France.
Alain SarauxRheumatologt, Université de Bretagne Occidentale, Brest, France.
Anne TournadreRheumatology, Université Clermont Auvergne, Clermont-Ferrand, France.
Adeline Ruyssen-WitrandRheumatology, Université Toulouse III Paul Sabatier, Toulouse, France.
Daniel WendlingRheumatology, Université de Franche-Comté, Besancon, France.ORCID 0000-0002-4687-5780
Philippe GoupilleRheumatology, Université de Tours, Tours, France.
Pascal ClaudepierreRheumatology, Hopital Albert Chenevier, Creteil, France.ORCID 0000-0003-1911-0544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the frequency of reporting composite indices evaluating axial spondyloarthritis (axSpA) disease activity in daily practice and to assess its impact on the secukinumab (SEC) retention rate.

methodsStudy design: Retrospective, multicentre. DATA COLLECTED: (1)

resultsA recommended composite index has been collected in 22% of the 906 enrolled axSpA patients. The percentage of patients still on treatment after 1, 2 and 3 years of follow-up was greater in those for whom at least one composite index had been optimally reported (respectively, 64% (57-71) vs 57% (54-61), 55% (48-62) vs 41% (38-45) and 52% (44-59) vs 38% (34-42), log rank test, p=0.016) with a lower risk of SEC discontinuation for these patients (HR: 0.70 (95% CI 0.5 to 0.88), Cox model, p=0.003).

conclusionThis study suggests that reporting of recommended composites indices for monitoring axSpA might be associated with higher retention rates of biological therapies.

Indexed as

Axial SpondyloarthritisAntibodies, Monoclonal, HumanizedHumansMedical RecordsOutcome Assessment, Health CareRetrospective StudiesSeverity of Illness IndexAntibodies, Monoclonal, Humanizedsecukinumabankylosinghealth careoutcome and process assessmentquality indicatorsspondylitis

Identifiers

PMID35301266
PMCPMC8932274

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.