ArticleNeurology(R) neuroimmunology & neuroinflammation2022
Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Quality Control for Retinal Optical Coherence Tomography Angiography in Multiple Sclerosis: A Validation Study of the OSCAR-MP Criteria.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Structural and Microvascular Changes in Demyelinating Optic Neuritis Assessed by OCT and OCTA: A 6-Month Longitudinal Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Optical Coherence Tomography Angiography Is Associated with Disease Activity Expressed by NEDA-3 Status in Patients with Relapsing Multiple Sclerosis.Journal of clinical medicine · 2025Article
- MOGJournal of neuroinflammation · 2025Review
- Barriers in Healthcare to the Use of Optical Coherence Tomography Angiography in Multiple Sclerosis.Neurology and therapy · 2025Review
- Ten Years ofNeurology(R) neuroimmunology & neuroinflammation · 2025Article
- Optical coherence tomography angiography suggests different retinal pathologies in multiple sclerosis and Sjögren's syndrome.Journal of neurology · 2024Article
- Retinal small vessel pathology is associated with disease burden in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Article
- The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.Neurology(R) neuroimmunology & neuroinflammation · 2023Review
- Retinal ganglion cell and microvascular density loss in hereditary spastic paraplegia.Restorative neurology and neuroscience · 2023Article
- Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis.Frontiers in immunology · 2023Observational
- Optical Coherence Tomography and Optical Coherence Tomography with Angiography in Multiple Sclerosis.Healthcare (Basel, Switzerland) · 2022Review
- Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis.Frontiers in immunology · 2022Observational
- Correlation analysis between foveal avascular zone and near peripheral retinal hypoperfusion in multiple sclerosis: a wide field optical coherence tomography angiography study.Frontiers in medicine · 2022Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesRarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function.
methodsThis prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA).
resultsRetinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses. DISCUSSION: Rarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers.
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