Evidence map›Paper›PMID 35301239›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

The Overlap Index as a Means of Evaluating Early Tau PET Signal Reliability.

Jeyeon Lee, Brian J Burkett, Hoon-Ki Min, Emily S Lundt, Sabrina M Albertson, Hugo Botha, Matthew L Senjem, Jeffrey L Gunter, Christopher G Schwarz, David T Jones and 4 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Subtracting First Principal Component May Improve 4R Tau Detectability on [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Tau PET overlap index correlation with neuropathological findings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jeyeon LeeDepartment of Radiology, Rochester, Minnesota; lee.jeyeon@mayo.edu.
Brian J BurkettDepartment of Radiology, Rochester, Minnesota.
Hoon-Ki MinDepartment of Radiology, Rochester, Minnesota.
Emily S LundtDepartment of Health Sciences Research, Rochester, Minnesota.
Sabrina M AlbertsonDepartment of Health Sciences Research, Rochester, Minnesota.
Hugo BothaDepartment of Neurology, Rochester, Minnesota; and.
Matthew L SenjemDepartment of Information Technology, Mayo Clinic, Rochester, Minnesota.
Jeffrey L GunterDepartment of Radiology, Rochester, Minnesota.
Christopher G SchwarzDepartment of Radiology, Rochester, Minnesota.
David T JonesDepartment of Neurology, Rochester, Minnesota; and.
David S KnopmanDepartment of Neurology, Rochester, Minnesota; and.
Clifford R JackDepartment of Radiology, Rochester, Minnesota.
Ronald C PetersenDepartment of Neurology, Rochester, Minnesota; and.
Val J LoweDepartment of Radiology, Rochester, Minnesota.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
PREDICTING ALZHEIMERS DISEASE WITH MAGNETIC RESONANCER01AG011378 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R. · 1993 to 2017
$12.1M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
Clinicopathologic and Neuroimaging Differences in Alzheimer's Disease VariantsR01AG054449 · NIA · MAYO CLINIC JACKSONVILLE · PI MURRAY, MELISSA ERIN · 2017 to 2021
$3.9M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
Tau PET/CT for Early Detection of Alzheimer’s Disease PathologyR01AG073282 · NIA · MAYO CLINIC ROCHESTER · PI LOWE, VAL JOHN, MURRAY, MELISSA ERIN · 2021 to 2025
$2.0M
The role of acetylation in regulating pathophysiology of tauR01NS089544 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD, WOLOZIN, BENJAMIN L · 2014 to 2018
$1.9M
PIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7M
Manipulating tau's posttranslational modifications to block disease progression in vivoR21NS094489 · NINDS · MAYO CLINIC JACKSONVILLE · PI COOK, CASEY N · 2015 to 2016
$430k
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG011378NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG054449NIA NIH HHS R01 AG073282NIA NIH HHS U01 AG006786NIDCD NIH HHS R01 DC010367NINDS NIH HHS R01 NS089544NINDS NIH HHS R01 NS089757NINDS NIH HHS R01 NS097495NINDS NIH HHS R21 NS094489
6 · The paper itself

Abstract

In tau PET, a reliable method to detect early tau accumulation in the brain is crucial. Noise, artifacts, and off-target uptake impede detection of subtle true-positive ligand binding. We hypothesize that identifying voxels with stable activity over time can enhance detection of true-positive tau.

Indexed as

Alzheimer DiseaseCognitive DysfunctionCarbolinesHumansNeurofibrillary TanglesPositron-Emission TomographyReproducibility of Resultstau ProteinsCarbolinestau ProteinsAV-1451early detectionflortaucipirtau PETvariability

Identifiers

PMID35301239
PMCPMC9635680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.