Evidence map›Paper›PMID 35301198›Full record

ArticleBMJ open respiratory research2022

Treatment patterns and frequency of key outcomes in acute severe asthma in children: a Paediatric Research in Emergency Departments International Collaborative (PREDICT) multicentre cohort study.

Simon Craig, Colin V E Powell, Gillian M Nixon, Ed Oakley, Jason Hort, David S Armstrong, Sarath Ranganathan, Amit Kochar, Catherine Wilson, Shane George and 20 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Management of asthma exacerbations in pediatric emergency departments across the United States.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 3 countries.

Simon CraigPaediatric Emergency Department, Monash Medical Centre, Monash Emergency Research Collaborative, Monash Health, Clayton, Victoria, Australia simon.craig@monash.edu.ORCID 0000-0003-2594-1643
Colin V E PowellDivision of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Gillian M NixonDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Ed OakleyEmergency Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Jason HortEmergency Department, Children's Hospital at Westmead, Westmead, New South Wales, Australia.
David S ArmstrongRespiratory and Sleep Medicine, Monash Children's Hospital, Clayton, Victoria, Australia.ORCID 0000-0002-5933-705X
Sarath RanganathanRespiratory Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Amit KocharEmergency Department, Women's and Children's Hospital Adelaide, North Adelaide, South Australia, Australia.
Catherine WilsonEmergency Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
Shane GeorgeSchool of Medicine and Dentistry, Griffith University, Southport, Queensland, Australia.ORCID 0000-0002-8880-1245
Natalie PhillipsChild Health Research Centre, Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.ORCID 0000-0002-7616-5712
Jeremy FurykEmergency Department, Townsville Hospital and Health Service, Townsville, Queensland, Australia.
Ben LawtonEmergency Department, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Meredith L BorlandEmergency Department, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Sharon O'BrienEmergency Department, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Jocelyn NeutzeKidz First Emergency Department, Middlemore Hospital, Auckland, New Zealand.
Anna LithgowDepartment of Paediatrics, Royal Darwin Hospital, Tiwi, Northern Territory of Australia, Australia.
Clare MitchellEmergency Department, Royal Darwin Hospital, Tiwi, Northern Territory of Australia, Australia.
Nick WatkinsEmergency Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Domhnall BranniganEmergency Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Joanna WoodEmergency Department, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Charmaine GrayEmergency Department, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Stephen HearpsMurdoch Childrens Research Institute, Parkville, Victoria, Australia.
Emma RamagePaediatric Emergency Department, Monash Medical Centre, Monash Emergency Research Collaborative, Monash Health, Clayton, Victoria, Australia.
Amanda WilliamsEmergency Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
Jamie LewEmergency Department, Canberra Hospital, Canberra, Australian Capital Territory, Australia.
Leonie JonesEmergency Department, Townsville Hospital and Health Service, Townsville, Queensland, Australia.
Andis GraudinsEmergency Department, Dandenong Hospital, Monash Emergency Research Collaborative, Monash Health, Clayton, Victoria, Australia.
Stuart DalzielEmergency Department, Starship Children's Health, Auckland, Auckland, New Zealand.
Franz E BablEmergency Department, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Murdoch Children's Research Institute · AURoyal Children's Hospital · AUFlinders Medical Centre · AUMonash Children’s Hospital · AUMonash Medical Centre · AURoyal Darwin Hospital · AURoyal Hobart Hospital · AUCanberra Hospital · AUCardiff University · GBCurtin University · AUGeelong Hospital · AUGriffith University · AULogan Hospital · AUMiddlemore Hospital · NZMonash Health · AUThe University of Queensland · AUThe University of Sydney · AUThe University of Western Australia · AUTownsville Hospital · AUUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleSevere acute paediatric asthma may require treatment escalation beyond systemic corticosteroids, inhaled bronchodilators and low-flow oxygen. Current large asthma datasets report parenteral therapy only.

objectivesTo identify the use and type of escalation of treatment in children presenting to hospital with acute severe asthma.

methodsRetrospective cohort study of children with an emergency department diagnosis of asthma or wheeze at 18 Australian and New Zealand hospitals. The main outcomes were use and type of escalation treatment (defined as any of intensive care unit admission, nebulised magnesium, respiratory support or parenteral bronchodilator treatment) and hospital length of stay (LOS). MEASUREMENTS AND MAIN

resultsOf 14 029 children (median age 3 (IQR 1-3) years; 62.9% male), 1020 (7.3%, 95% CI 6.9% to 7.7%) had treatment escalation. Children with treatment escalation had a longer LOS (44.2 hours, IQR 27.3-63.2 hours) than children without escalation 6.7 hours, IQR 3.5-16.3 hours; p<0.001). The most common treatment escalations were respiratory support alone (400; 2.9%, 95% CI 2.6% to 3.1%), parenteral bronchodilator treatment alone (380; 2.7%, 95% CI 2.5% to 3.0%) and both respiratory support and parenteral bronchodilator treatment (209; 1.5%, 95% CI 1.3% to 1.7%). Respiratory support was predominantly nasal high-flow therapy (99.0%). The most common intravenous medication regimens were: magnesium alone (50.4%), magnesium and aminophylline (24.6%) and magnesium and salbutamol (10.0%).

conclusionsOverall, 7.3% children with acute severe asthma received some form of escalated treatment, with 4.2% receiving parenteral bronchodilators and 4.3% respiratory support. There is wide variation treatment escalation.

Indexed as

AsthmaAustraliaChildChild, PreschoolCohort StudiesEmergency Service, HospitalFemaleHumansInfantMaleRetrospective Studiespaediatric asthma

Identifiers

PMID35301198
PMCPMC8932260
OpenAlexW4220938591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.