Evidence map›Paper›PMID 35301137›Full record

ArticleBioorganic & medicinal chemistry letters2022

nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity.

Madeline M Dekarske, Lewis Oscar Felix, Carlos Monteagudo Ortiz, Erika E Csatary, Elefterios Mylonakis, William M Wuest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madeline M DekarskeDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, United States.
Lewis Oscar FelixDivision of Infectious Diseases, Rhode Island Hospital and Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence Rhode Island 02903, United States.
Carlos Monteagudo OrtizDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, United States.
Erika E CsataryDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, United States.
Elefterios MylonakisDivision of Infectious Diseases, Rhode Island Hospital and Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence Rhode Island 02903, United States.
William M WuestDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, United States. Electronic address: wwuest@emory.edu.

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
NIAID NIH HHS P01 AI083214NIGMS NIH HHS R35 GM119426
6 · The paper itself

Abstract

nTZDpa kills both growing and persister Staphylococcus aureus. However, due to toxicity liabilities, our lab conducted two structure-activity relationship (SAR) studies focusing on the core scaffold and obtained a new lead compound that was more potent and less hemolytic. Despite these favorable changes, the new lead displayed toxicity to renal cells. In this SAR study, we sought to improve this renal toxicity by derivatization via changes to sp

Indexed as

Anti-Infective AgentsStaphylococcal InfectionsAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsPPAR gammaStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsPPAR gammaAntibiotic resistancenTZDpaRenal toxicity

Identifiers

PMID35301137
PMCPMC9019844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.