SynthesisContemporary clinical trials2022
Towards a more patient-centered clinical trial process: A systematic review of interventions incorporating health literacy best practices.
Synthesis in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- A randomized control trial of re-designed and shorter research informed consent forms to improve comprehension.Clinical trials (London, England) · 2026Trial
- A randomized controlled trial of a health literacy-based digital intervention to promote postpartum recovery and self-care.Scientific reports · 2026Trial
- Improving cancer clinical trial enrollment and patient understanding using TrialTalk, a structured communication method: a pilot randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial.Scientific reports · 2025Trial
- Trial
- Understanding Cancer Clinical Trial Participation in Rural Communities: A Qualitative Focus Group Study.Psycho-oncology · 2026Article
- Changes in Nurse-Patient Communication Through Health Technologies and Nursing Practices to Recognize and Support Limited Digital Health Literacy: Qualitative Study.JMIR nursing · 2026Article
- Readability of informed consent forms from ClinicalTrials.gov in ketamine clinical trials for mental health conditions: a cross-sectional analysis.Therapeutic advances in psychopharmacology · 2026Article
- Competence to Consent and Willingness to Participate in Behavioral Trials Among a Mixed HIV Serostatus Sample of Young Gay and Bisexual Men Who Use Stimulants: A Mixed-Methods Study.Substance use & misuse · 2026Article
- Health Literacy Recommendations for Digital Mental Health Treatments.Health literacy research and practice · 2026Article
- Designing an effective pulmonary rehabilitation program for severe asthma.Frontiers in medicine · 2026Article
- Feeding intelligence: comparative evaluation of ChatGPT and clinical guidelines for nutritional management in head and neck cancer.Journal of translational medicine · 2025Article
- The Questions, Challenges, and Possibilities When Joining Critical Disabilities Studies and Healthcare Research.Healthcare (Basel, Switzerland) · 2025Article
- Readability of Public-Facing Urologic Oncology Trial Summaries on ClinicalTrials.gov.Urology practice · 2025Article
- An Information App (e-TOP) to Support Parents' Information Needs During the First Year at Home After Preterm Birth: Development and Usability Study.JMIR pediatrics and parenting · 2025Article
- Health Literacy Applications in Patients With Cancer.Clinical journal of oncology nursing · 2025Review
- Characterizing the Research Participant Recruitment Funnel for Alzheimer's Secondary Prevention Trials: Results from A National Survey of U.S. Adults.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Primary and Emergency Care Use: The Roles of Health Literacy, Patient Activation, and Sleep Quality in a Latent Profile Analysis.Behavioral sciences (Basel, Switzerland) · 2025Article
- Assessment of readability of gynecologic cancer clinical trials literature at National Cancer Institute-designated Comprehensive Cancer Centers.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2025Article
- Clinical trial knowledge, discussion, and participation among cancer survivors: A HINTS-SEER study.Patient education and counseling · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundA 2019 public workshop convened by the National Academies of Sciences, Engineering and Medicine (NASEM) Roundtable on Health Literacy identified a need to develop evidence-based guidance for best practices for health literacy and patient activation in clinical trials. PURPOSE: To identify studies of health literacy interventions within medical care or clinical trial settings that were associated with improved measures of health literacy or patient activation, to help inform best practices in the clinical trial process. DATA SOURCES: Literature searches were conducted in PubMed, the Cumulative Index to Nursing and Allied Health Literature, SCOPUS, Cochrane, and Web of Science from January 2009 to June 2021. STUDY SELECTION: Of 3592 records screened, 22 records investigating 27 unique health literacy interventions in randomized controlled studies were included for qualitative synthesis. DATA EXTRACTION: Data screening and abstraction were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. DATA SYNTHESIS: Types of health literacy interventions were multimedia or technology-based (11 studies), simplification of written material (six studies) and in-person sessions (five studies). These interventions were applied at various stages in the healthcare and clinical trial process. All studies used unique outcome measures, including patient comprehension, quality of informed consent, and patient activation and engagement.
conclusionsThe findings of our study suggest that best practice guidelines recommend health literacy interventions during the clinical trial process, presentation of information in multiple forms, involvement of patients in information optimization, and improved standardization in health literacy outcome measures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.