Evidence map›Paper›PMID 35300872›Full record

ArticleVaccine2022

Nepal measles outbreak response immunization during COVID-19: A risk-based intervention strategy.

Anindya Sekhar Bose, Pasang Rai, Binod Prasad Gupta, Rahul Pradhan, Mona Lacoul, Sushil Shakya, Dipesh Shrestha, Abhiyan Gautam, Bharat Bhandari, Basanta Shrestha and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 7 countries.

Anindya Sekhar BoseWorld Health Organization (WHO), Department of Immunization Vaccines and Biologicals (IVB), Geneva, Switzerland. Electronic address: BoseA@who.int.
Pasang RaiWHO Immunization Preventable Disease (IPD) Programme, Nepal. Electronic address: RaiP@who.int.
Binod Prasad GuptaWHO Emergencies Programme (WHE), Nepal. Electronic address: GuptaB@who.int.
Rahul PradhanWHO IPD, Nepal. Electronic address: PradhanR@who.int.
Mona LacoulWHO IPD, Nepal. Electronic address: LacoulM@who.int.
Sushil ShakyaWHO IPD, Nepal. Electronic address: ShakyaSu@who.int.
Dipesh ShresthaWHO IPD, Nepal. Electronic address: ShresthaDi@who.int.
Abhiyan GautamWHO IPD, Nepal. Electronic address: GautamA@who.int.
Bharat BhandariFamily Welfare Division (FWD), Dept of Health Services (DOHS), Nepal. Electronic address: sijapati.bharat40@gmail.com.
Basanta ShresthaFWD, DOHS, Nepal. Electronic address: basanta.stha44@gmail.com.
Bhim Singh TinkariManagement Division, Dept of Health Services, Nepal. Electronic address: drtinkari@gmail.com.
Runa JhaNational Public Health Laboratory (NPHL), Ministry of Health and Population, Nepal. Electronic address: runa75jha@gmail.com.
Basudha KhanalBP Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal. Electronic address: basudhak@gmail.com.
Pradeep ShresthaUnited Nations Children's Fund (UNICEF), Nepal. Electronic address: pshrestha@unicef.org.
Sushma BhusalUNICEF Nepal and Norwegian Red Cross, Nepal. Electronic address: sushma.bhusal@redcross.no.
Jhalak Sharma GautamFWD, DOHS, Nepal. Electronic address: jgautamdr@gmail.com.
National Immunization Advisory Committee
World Health Organization - Afghanistan · AFB.P. Koirala Institute of Health Sciences · NPDepartment of Health & Family Welfare · INDepartment of Health Services · NPGovernment of Nepal · NPMinistry of Health and Population · NPNepal Development Research Institute · NPNepal Red Cross Society · NPUnited Nations Children's Fund · USWorld Health Organization · CHWorld Health Organization - Pakistan · PK

Funding

World Health Organization 001
6 · The paper itself

Abstract

In 2020, National Immunization Programme (NIP) of Nepal implemented a measles outbreak response immunization (ORI) campaign, which was additional to an ongoing preventive measles-rubella SIA campaign. Both campaigns were implemented during ongoing COVID-19 transmission. By April, 220 measles cases and two deaths were confirmed from eight districts of Nepal. The NIP triangulated information from surveillance (measles and COVID-19), measles immunization performance and immunity profile, programme capacities and community engagement and applied a logical decision-making framework to the collated data to inform 'Go/No-Go' decisions for ORI interventions. This was reviewed by the National Immunization Advisory Committee (NIAC) for endorsement. Outbreak response with non-selective immunization (ORI), vitamin-A administration and case management were implemented in affected municipalities of four districts, while in the remaining districts outbreak response without ORI were undertaken. The structure and iterative application of this logical framework has been described. ORI was implemented without interrupting the ongoing measles-rubella vaccination campaign which had targeted children from 9 to 59 months of age. The age group for ORI was same as SIA in one sub-district area, while for the other three sub-district areas it was from 6 months to 15 years of age. More than 32,000 persons (97% coverage) were vaccinated in ORI response. Overall measles incidence decreased by 98% after ORI. The daily incidence rate of measles was 94 times higher (95% confidence interval: 36.11 - 347.62) before the ORI compared to two weeks after ORI until year end. Close attention to surveillance and other data to inform actions and seamless collaboration between NIP and core immunization partners (WHO, UNICEF), with guidance from NIAC were key elements in successful implementation. This was an example of feasible application of the global framework for implementation of a mass vaccination campaign during COVID-19 through application of a simple decision-making logical framework.

Indexed as

COVID-19MeaslesRubellaChildDisease OutbreaksHumansImmunizationNepalCOVID-19ImmunizationMeaslesNepalNITAGOutbreak response

Identifiers

PMID35300872
PMCPMC8882431
OpenAlexW4214704493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.