Trial reportJournal of neuroengineering and rehabilitation2022
Bimanual motor skill learning with robotics in chronic stroke: comparison between minimally impaired and moderately impaired patients, and healthy individuals.
Trial report in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03974750 (Bimanual Motor Skill Learning Through Robotics in Stroke Survivors and Healthy Individuals), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bimanual Motor Skill Learning Through Robotics in Stroke Survivors and Healthy Individuals
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Effects of robot-assisted task-oriented training on upper limb function and activities of daily living in patients with stroke: A systematic review.The Journal of international medical research · 2026Pooled it
- Behavioral and neurophysiological changes associated with a single session of bimanual task practice after stroke.Clinical neurophysiology practice · 2026Article
- Efficacy of Robot-assisted Training on Upper Limb Motor Function After Stroke: A Systematic Review and Network Meta-analysis.Archives of rehabilitation research and clinical translation · 2025Review
- Article
- Relationships Between Cognitive Impairments and Motor Learning After Stroke: A Scoping Review.Neurorehabilitation and neural repair · 2025Article
- Tailoring robot-assisted arm training to individuals with stroke: bridging neuroscience principles and clinical practice.Frontiers in neurology · 2025Article
- Rest the brain to learn new gait patterns after stroke.Journal of neuroengineering and rehabilitation · 2024Article
- Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke.Experimental brain research · 2024Article
- Rest the Brain to Learn New Gait Patterns after Stroke.medRxiv : the preprint server for health sciences · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost activities of daily life (ADL) require cooperative bimanual movements. A unilateral stroke may severely impair bimanual ADL. How patients with stroke (re)learn to coordinate their upper limbs (ULs) is largely unknown. The objectives are to determine whether patients with chronic supratentorial stroke could achieve bimanual motor skill learning (bim-MSkL) and to compare bim-MSkL between patients and healthy individuals (HIs).
methodsTwenty-four patients and ten HIs trained over 3 consecutive days on an asymmetrical bimanual coordination task (CIRCUIT) implemented as a serious game in the REAplan® robot. With a common cursor controlled by coordinated movements of the ULs through robotic handles, they performed as many laps as possible (speed constraint) on the CIRCUIT while keeping the cursor within the track (accuracy constraint). The primary outcome was a bimanual speed/accuracy trade-off (biSAT), we used a bimanual coordination factor (biCO) and bimanual forces (biFOP) for the secondary outcomes. Several clinical scales were used to evaluate motor and cognitive functions.
resultsOverall, the patients showed improvements on biSAT and biCO. Based on biSAT progression, the HI achieved a larger bim-MSkL than the patients with mild to moderate impairment (Fugl-Meyer Assessment Upper Extremity (FMA-UE): 28-55, n = 15) but not significantly different from those with minimal motor impairment (FMA-UE: 66, n = 9). There was a significant positive correlation between biSAT evolution and the FMA-UE and Stroke Impact Scale.
conclusionsBoth HI and patients with chronic stroke training on a robotic device achieved bim-MSkL, although the more impaired patients were less efficient. Bim-MSkL with REAplan® may be interesting for neurorehabilitation after stroke.
trial registrationClinicalTrial.gov identifier: NCT03974750. Registered 05 June 2019. https://clinicaltrials.gov/ct2/show/NCT03974750?cond=NCT03974750&draw=2&rank=1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.