Evidence map›Paper›PMID 35300599›Full record

Trial reportBMC neurology2022

A patient-initiated treatment model for blepharospasm and hemifacial spasm: a randomized controlled trial.

Sadie Lawes-Wickwar, Hayley McBain, Stefano Brini, Shashivadan P Hirani, Catherine S Hurt, Chris Flood, Nicola Dunlop, Dianne Solly, Bridget Crampton, Stanton P Newman and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02577224 (A Randomised Controlled Trial to Explore the Effectiveness and Cost-effectiveness of a Patient-initiated Botulinum Toxin Treatment Model for Blepharospasm and Hemifacial Spasm Compared to Treatment as Usual), which is not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02577224 nacompletednot on this map

A Randomised Controlled Trial to Explore the Effectiveness and Cost-effectiveness of a Patient-initiated Botulinum Toxin Treatment Model for Blepharospasm and Hemifacial Spasm Compared to Treatment as Usual

TypeinterventionalSponsorMoorfields Eye Hospital NHS Foundation TrustRan2015 to 2018Enrolled130ConditionsBlepharospasm, Hemi Facial SpasmArmsPatient-initiated treatment
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sadie Lawes-Wickwar *City, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK. sadie.wickwar.2@city.ac.uk.ORCID http://orcid.org/0000-0001-9307-4532
Hayley McBain *City, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK.ORCID https://orcid.org/0000-0002-6742-1104
Stefano BriniCity, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK.ORCID https://orcid.org/0000-0002-1909-1796
Shashivadan P HiraniCity, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK.ORCID https://orcid.org/0000-0002-1577-8806
Catherine S HurtCity, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK.ORCID https://orcid.org/0000-0003-1571-0040
Chris FloodLondon South Bank University, School of Health and Social Care, London, UK.ORCID https://orcid.org/0000-0001-5170-7792
Nicola DunlopMoorfields Eye Hospital NHS Foundation Trust, Adnexal Department, London, UK.ORCID https://orcid.org/0000-0001-6092-721X
Dianne SollyPublic Contributor, London, UK.
Bridget CramptonPublic Contributor, London, UK.
Stanton P NewmanCity, University of London, School of Health Sciences, 10 Northampton Square, London, EC1V 0HB, UK.ORCID https://orcid.org/0000-0001-6712-6079
Daniel G EzraMoorfields Eye Hospital NHS Foundation Trust, Adnexal Department, London, UK.ORCID https://orcid.org/0000-0002-3565-1167
City, University of London · GBMoorfields Eye Hospital NHS Foundation Trust · GBLondon South Bank University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo test, in a two-arm, single center, superiority, randomized controlled trial, the effectiveness of and costs associated with a patient-initiated treatment model for people with hemifacial spasm (HFS) and blepharospasm (BEB) in comparison to usual care.

methodsOne hundred and thirty patients with HFS or BEB, aged 18 years or over, were recruited from a nurse-led botulinum toxin type A clinic at an eye hospital in the United Kingdom (UK), completed baseline measures and were randomized (1:1). The intervention group determined their own botulinum toxin type A (BoNT/A) treatment schedule during the trial period (9 months) and received an information leaflet with a "hotline" number to book an appointment. Usual care appointments were scheduled by treating clinicians. Data analysts were blind to study group. The primary outcomes were disease severity and functional disability, as measured by the Jankovic Rating Scale and Blepharospasm Disability Index, respectively. Secondary outcomes included quality of life, anxiety and depression, satisfaction with care, confidence in the service, economic costs and employment days lost.

resultsSixty-five patients were randomized to each group. The intervention demonstrated no statistically significant difference to usual care for any of primary outcomes. On secondary outcomes the levels of anxiety differed significantly (F

conclusionsWe did not observe differences between the patient-initiated treatment model and usual care for people with BEB or HFS, on any primary outcome measure, quality of life, or depression. The patient-initiated treatment model may, however, have the potential to save healthcare costs and reduce anxiety. Patients using this new model were also equally as satisfied in the service and confident in their care as those receiving treatment as usual.

trial registrationClinicaltrials.gov ID NCT02577224 , 16th October 2015.

Indexed as

BlepharospasmBotulinum Toxins, Type AHemifacial SpasmAdolescentAdultAgedAged, 80 and overHealth Care CostsHumansMiddle AgedQuality of LifeYoung AdultBotulinum Toxins, Type ABlepharospasmBotulinum toxinDystoniaHemifacial spasmPatient-initiated servicesRandomized controlled trial

Identifiers

PMID35300599
PMCPMC8928587
OpenAlexW4221038432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.