Evidence map›Paper›PMID 35300484›Full record

ReviewFrontiers in microbiology2022

The Role of Bacterial Membrane Vesicles in Human Health and Disease.

Daniel N Villageliu, Derrick R Samuelson

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Tregs and persistentFrontiers in oral health · 2026
    Article
  10. A distinct subpopulation of membrane vesicles inApplied and environmental microbiology · 2025
    Article
  11. Article
  12. Review
  13. Towards EffectiveInternational journal of molecular sciences · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. EnterohemorrhagicFrontiers in cellular and infection microbiology · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel N VillageliuDivision of Pulmonary, Critical Care, and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Derrick R SamuelsonDivision of Pulmonary, Critical Care, and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Funding

Mechanisms by Which Alcohol-Induced Dysbiosis Impairs Host Defense Against Klebsiella PneumoniaeR00AA026336 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SAMUELSON, DERRICK R · 2019 to 2021
$743k
Mechanisms by Which Alcohol-Induced Dysbiosis Impairs Host Defense Against Klebsiella PneumoniaeK99AA026336 · NIAAA · LSU HEALTH SCIENCES CENTER · PI SAMUELSON, DERRICK R · 2018 to 2019
$263k
NIAAA NIH HHS K99 AA026336NIAAA NIH HHS R00 AA026336
6 · The paper itself

Abstract

Bacterial membrane vesicles (MVs) are nanoparticles derived from the membrane components of bacteria that transport microbial derived substances. MVs are ubiquitous across a variety of terrestrial and marine environments and vary widely in their composition and function. Membrane vesicle functional diversity is staggering: MVs facilitate intercellular communication by delivering quorum signals, genetic information, and small molecules active against a variety of receptors. MVs can deliver destructive virulence factors, alter the composition of the microbiota, take part in the formation of biofilms, assist in the uptake of nutrients, and serve as a chemical waste removal system for bacteria. MVs also facilitate host-microbe interactions including communication. Released in mass, MVs overwhelm the host immune system and injure host tissues; however, there is also evidence that vesicles may take part in processes which promote host health. This review will examine the ascribed functions of MVs within the context of human health and disease.

Indexed as

bacterial membrane vesiclesbacterial nanoparticlesimmunitymicrobial endocrinologyOMVsignaling

Identifiers

PMID35300484
PMCPMC8923303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.