Evidence map›Paper›PMID 35300481›Full record

ArticleFrontiers in microbiology2022

The Variation of Duck RIG-I-Mediated Innate Immune Response Induced by Different Virulence Avian Influenza Viruses.

Boyu Zhai, Lanlan Liu, Xiang Li, Xinru Lv, Jinyan Wu, Jing Li, Shengze Lin, Yuxiang Yin, Jiaqi Lan, Jianan Du and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Duck CD8Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Boyu ZhaiState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Lanlan LiuCollege of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, China.
Xiang LiState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Xinru LvState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Jinyan WuState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Jing LiState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Shengze LinState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yuxiang YinState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Jiaqi LanState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Jianan DuState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Chenwei WuState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yi WenState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yajun WangState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yulong WangState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Zhijun HouState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yanbing LiChinese Academy of Agricultural Sciences Harbin Veterinary Research Institute, Harbin, China.
Hongliang ChaiState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Xiangwei ZengState Forestry Administration Key Laboratory of Wildlife Conservation, College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Northeast Forestry University · CNHarbin Veterinary Research Institute · CNHeilongjiang University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the emerging highly pathogenic avian influenza (HPAI) A(H5N8) virus has been reported with features of widely spread, an expanding host range, and cross-species transmission, attracting wide attention. The domestic duck plays a major role in the epidemiological cycle of the HPAI H5N8 virus, but little is known concerning innate immune responses during influenza infection in duck species. In this study, we used two wild-bird-origin viruses, H5N8 and H4N6, to conduct duck infection experiments, and detect the load of the two viruses, and retinoic acid-inducible gene I (RIG-I) and interferon β (IFN-β) in the host's natural immune response. Through comparison, it is found that the expression levels of RIG-I and IFN-β are both fluctuating. The innate immunity starts rapidly within 6 h after infection and is inhibited by the virus to varying degrees. The expression of RIG-I and IFN-β decreased on 1-2 days post-infection (dpi). The HPAI H5N8 virus has a stronger inhibitory effect on RIG-I than the low pathogenic avian influenza (LPAI) H4N6 virus and is the strongest in the lungs. After infection with HPAI H5N8 virus, 2 dpi, viral RNA replicates in large amounts in the lungs. It has been proven that RIG-I and IFN-β play an important role in the innate immune response of ducks to HPAI H5N8 virus infection, especially in the lungs. The main battlefield of RIG-I and IFN-β after infection with the LPAI H4N6 virus is in the rectum. Both viruses have been effectively controlled after 7 dpi. These results will help to understand the transmission mechanisms of avian influenza virus in wild ducks and help effectively prevent and control avian influenza.

Indexed as

AIVduckH4N6H5N8IFN-βlungrectumRIG-I

Identifiers

PMID35300481
PMCPMC8921926
OpenAlexW4214766371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.