Evidence map›Paper›PMID 35300412›Full record

ReviewFrontiers in cell and developmental biology2022

BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies.

Xiaoyu Fu, Wei Tan, Qibin Song, Huadong Pei, Juanjuan Li

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pathogenic variants inJournal of medicine and life · 2025
    Pooled it
  2. Review
  3. Review
  4. Identification and Computational Analysis ofMedical sciences (Basel, Switzerland) · 2026
    Article
  5. Assessing the Clinical Relevance ofCurrent oncology (Toronto, Ont.) · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Research progress of DUB enzyme in breast cancer.Clinical and experimental medicine · 2025
    Review
  18. Article
  19. Therapeutic Potential of Metal-Based and PARP Inhibitor Chemotherapy forInternational journal of molecular sciences · 2025
    Review
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Xiaoyu FuDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Wei TanDepartment of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Qibin SongCancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
Huadong PeiDepartment of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States.
Juanjuan LiDepartment of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Wuhan University · CNGeorgetown University · USGeorge Washington University · USRenmin Hospital of Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer susceptibility gene 1 (

Indexed as

BRCA1breast cancerdetectiongene mutationpersonalized and precision medicine (PPM)

Identifiers

PMID35300412
PMCPMC8921524
OpenAlexW4214728644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.