Evidence map›Paper›PMID 35300375›Full record

ArticleFrontiers in cellular and infection microbiology2022

Nitrite Triggers Reprogramming of the Oral Polymicrobial Metabolome by a Commensal Streptococcus.

Joshua T Huffines, Sara N Stoner, Joshua J Baty, Jessica A Scoffield

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024
    Article
  4. One-carbon metabolism and microbial pathogenicity.Molecular oral microbiology · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joshua T HuffinesDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Sara N StonerDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Joshua J BatyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Jessica A ScoffieldDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Elucidating the role of reactive nitrogen species in bacterial interactionsR35GM142748 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCOFFIELD, JESSICA A · 2021 to 2025
$1.9M
UAB Predoctoral Training Program in Lung DiseasesT32HL134640 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWORDS, WILLIAM E · 2017 to 2021
$1.0M
Inhibition of Streptococcus mutans by oral commensal streptococci and nitrie-mediated activityR00DE025913 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCOFFIELD, JESSICA A · 2018 to 2020
$749k
Interactions between Pseudomonas aeruginosa and Streptococcus salivarius and effects on the host immune responseF31HL162487 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STONER, SARA N · 2022 to 2023
$57k
NHLBI NIH HHS F31 HL162487NHLBI NIH HHS T32 HL134640NIDCR NIH HHS R00 DE025913NIDCR NIH HHS T90 DE022736NIGMS NIH HHS R35 GM142748NIGMS NIH HHS T32 GM008111
6 · The paper itself

Abstract

Commensal streptococci regulate health and homeostasis within oral polymicrobial communities. Remarkably, high salivary nitrite concentrations have also been associated with improved health in the oral cavity. We previously demonstrated that nitrite assists hydrogen peroxide-producing oral commensal streptococci in regulating homeostasis

Indexed as

NitritesStreptococcusMetabolomeMouthSymbiosisNitritesbacterial competitionnitriteoral commensalpolymicrobialreactive nitrogen species

Identifiers

PMID35300375
PMCPMC8923425
OpenAlexW4214693036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.