Evidence map›Paper›PMID 35300342›Full record

ArticleFrontiers in immunology2022

IFN-γ-Primed hUCMSCs Significantly Reduced Inflammation

Xiao Ling, Teng Wang, Chao Han, Pin Wang, Xiaoli Liu, Chengyun Zheng, Jianzhong Bi, Xiaoyan Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  8. VCAM-1Neurochemical research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiao LingDepartment of Gynaecology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Teng WangDepartment of Digestive Internal Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Chao HanDepartment of Neurosurgery, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Pin WangDepartment of Neurology Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiaoli LiuDepartment of Hematology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Chengyun ZhengDepartment of Hematology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Jianzhong BiDepartment of Neurology Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiaoyan ZhouDepartment of Neurology Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Second Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating the expression of indoleamine 2,3-dioxygenease. Therefore, we treated experimental autoimmune encephalomyelitis (EAE) mice, an animal model of multiple sclerosis (MS), with IFN-γ-primed human umbilical cord MSCs (IFN-γ-hUCMSCs). This study aimed to investigate the potential therapeutic effects of IFN-γ-hUCMSCs transplantation and to identify the biological pathways involved in EAE mice. Firstly, the body weights and clinical scores of EAE mice were recorded before and after treatment. Then, the inflammatory cytokine levels in splenic cell supernatants were quantified by enzyme-linked immunosorbent assay. Finally, the mRNA expression levels of signal transducer and activator of transduction 3 (

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsCytokinesDisease Models, AnimalForkhead Transcription FactorsHumansInflammationInterferon-gammaMiceMice, Inbred C57BLNuclear Receptor Subfamily 1, Group F, Member 3Signal TransductionSTAT3 Transcription FactorUmbilical CordCytokinesForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseInterferon-gammaNuclear Receptor Subfamily 1, Group F, Member 3STAT3 protein, humanSTAT3 Transcription Factorexperimental autoimmune encephalomyelitis (EAE)Foxp3/ROR-γt/STAT3 signaling pathwayIFN-γ-primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs)indoleamine 2,3-dioxygenease (IDO)multiple sclerosis (MS)

Identifiers

PMID35300342
PMCPMC8921983
OpenAlexW4214496040

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.