ArticleFrontiers in veterinary science2022
Combined Effects of Temperature and Salinity on the Pharmacokinetics of Florfenicol in Nile Tilapia (
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 18 citations in OpenAlex.
- Water temperature differentially affects muscle residue depletion of doxycycline and flumequine in olive flounder (Paralichthys olivaceus).Veterinary research communications · 2026Article
- Article
- Gender-specific responses in gene expression of Nile tilapia (Oreochromis niloticus) to heavy metal pollution in different aquatic habitats.Scientific reports · 2024Article
- Are fish immunocompetent enough to face climate change?Biology letters · 2024Review
- Pond water quality and its relation to fish yield and disease occurrence in small-scale aquaculture in arid areas.Heliyon · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
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Abstract
Prudent antimicrobial use requires knowledge of pharmacokinetics (PK) in a specific fish species which in turn depends on water temperature and salinity. Although the influence of each individual factor is known, the combined effect is less clear. The objective of the current study was to investigate the effect of temperature and salinity concurrently on the PK of florfenicol (FF) in Nile tilapia reared in brackish water. Twenty-eight fish were divided into four groups and kept at one of two temperatures (24 vs. 32°C) and two salinity levels (5 vs. 15 ppt). The FF was administered at a single dose of 15 mg/kg body weight via oral gavage. The serum concentrations were analyzed by HPLC method and the PK parameters were analyzed by a 2-compartmental model. The result revealed that at 32°C, the elimination half-lives (t
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