Evidence map›Paper›PMID 35300196›Full record

ReviewADMET & DMPK2020

Electrospun nanofibers: A nanotechnological approach for drug delivery and dissolution optimization in poorly water-soluble drugs.

Luis Castillo-Henríquez, Rolando Vargas-Zúñiga, Jorge Pacheco-Molina, Jose Vega-Baudrit

Abstract readReview
In one paragraph

Review in ADMET & DMPK, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luis Castillo-HenríquezPhysical Chemistry Laboratory, Faculty of Pharmacy, University of Costa Rica, 11501-2060, San José, Costa Rica.
Rolando Vargas-ZúñigaPhysical Chemistry Laboratory, Faculty of Pharmacy, University of Costa Rica, 11501-2060, San José, Costa Rica.
Jorge Pacheco-MolinaLaboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Costa Rica, 11501-2060, San José, Costa Rica.
Jose Vega-BaudritNational Laboratory of Nanotechnology (LANOTEC), National Center for High Technology (CeNAT), 1174-1200, San José, Costa Rica.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospinning is a novel and sophisticated technique for the production of nanofibers with high surface area, extreme porous structure, small pore size, and surface morphologies that make them suitable for biomedical and bioengineering applications, which can provide solutions to current drug delivery issues of poorly water-soluble drugs. Electrospun nanofibers can be obtained through different methods asides from the conventional one, such as coaxial, multi-jet, side by side, emulsion, and melt electrospinning. In general, the application of an electric potential to a polymer solution causes a charged liquid jet that moves downfield to an oppositely charged collector, where the nanofibers are deposited. Plenty of polymers that differ in their origin, degradation character and water affinity are used during the process. Physicochemical properties of the drug, polymer(s), and solvent systems need to be addressed to guarantee successful manufacturing. Therefore, this review summarizes the recent progress in electrospun nanofibers for their use as a nanotechnological tool for dissolution optimization and drug delivery systems for poorly water-soluble drugs.

Indexed as

Drug developmentDrug loadingDrug releaseElectrospinningNanotechnologyPolymersSolubility

Identifiers

PMID35300196
PMCPMC8915594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.