ArticleThe Lancet regional health. Western Pacific2022
Clinical characteristics of the first three waves of hospitalised patients with COVID-19 in Japan prior to the widespread use of vaccination: a nationwide observational study.
Article in The Lancet regional health. Western Pacific, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and outcome of SARS-CoV-2 reinfection in the pre-Omicron era: A global systematic review and meta-analysis.Journal of global health · 2023Pooled it
- Healthcare utilization among Japanese older adults during later stage of prolonged pandemic.Scientific reports · 2025Article
- Exploring the diverse factors influencing healthcare utilization during the COVID-19 crisis.Frontiers in public health · 2025Article
- Long COVID among the first three waves of COVID-19 in Japan: a multicentre cohort study.BMJ open respiratory research · 2024Article
- Public Health and Economic Impact of Periodic COVID-19 Vaccination with BNT162b2 for Old Adults and High-Risk Patients in an Illustrative Prefecture of Japan: A Budget Impact Analysis.Infectious diseases and therapy · 2024Article
- The Behaviour of IL-6 and Its Soluble Receptor Complex during Different Waves of the COVID-19 Pandemic.Life (Basel, Switzerland) · 2024Article
- Comparative analysis of mortality in patients admitted with an infection with influenza A/B virus, respiratory syncytial virus, rhinovirus, metapneumovirus or SARS-CoV-2.Influenza and other respiratory viruses · 2024Article
- Observational
- Pitfalls and biases in neuroepidemiological studies of COVID-19 and the nervous system: a critical appraisal of the current evidence and future directions.Journal of neurology · 2023Review
- Article
- Impacts of the COVID-19 pandemic on life expectancy at birth in Asia.BMC public health · 2023Article
- Article
- Peculiar weather patterns effects on air pollution and COVID-19 spread in Tokyo metropolis.Environmental research · 2023Observational
- Characteristics of hospitalized COVID-19 patients with other respiratory pathogens identified by rapid diagnostic test.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023Article
- Regional trends in the use of steroids and favipiravir for COVID-19 treatment.Journal of infection and public health · 2023Article
- Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities.Frontiers in immunology · 2023Article
- Statistical Analysis of Mortality Rates of Coronavirus Disease 2019 (COVID-19) Patients in Japan Across the 4C Mortality Score Risk Groups, Age Groups, and Epidemiological Waves: A Report From the Nationwide COVID-19 Cohort.Open forum infectious diseases · 2023Article
- Do selected lifestyle parameters affect the severity and symptoms of COVID-19 among elderly patients? The retrospective evaluation of individuals from the STOP-COVID registry of the PoLoCOV study.Journal of infection and public health · 2023Article
- Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan.Scientific reports · 2022Article
- Article
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21 authors.
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Abstract
Background: Before widespread coronavirus disease (COVID-19) vaccinations, Japan experienced three COVID-19 epidemic waves. This study aimed to evaluate the characteristics of hospitalised COVID-19 patients and reveal temporal changes. Methods: This study included 33,554 hospitalised patients with COVID-19 from 553 healthcare facilities. Data were analysed by age group and epidemic wave (first wave, 01/01/2020-05/31/2020; second wave, 06/01/2020-10/31/2020; and third wave, 11/01/2020-03/31/2021). Findings: By age group, 3% (under 18), 22% (young), 34% (middle-aged), and 41% (older patients) were aged 0-17, 18-39, 40-64, and >65 years; while 16%, 35%, and 49% were in the first, second, and third wave, respectively. The patients' overall median age (58 years; interquartile range, 39-74) was lowest and highest during the second and third waves, respectively. The frequency of any comorbidity was lowest and highest during the second (44·5%) and third (63·6%) waves, respectively. The symptoms at admission and exposure history differed considerably with age. The overall case fatality rate (5%) was highest among older patients (11·4%). Case fatality rate was highest and lowest during the first (7·3%) and second (2·8%) waves, respectively. Medication use changed over time. Interpretation: Although the overall case fatality rate remained relatively low, it was more than twice as high among older patients. After adjusting for age and comorbidities, the risk of death was highest in the first wave. Funding: This work was supported by the Ministry of Health, Labour and Welfare "Research on Emerging and Re-emerging Infectious Diseases and Immunization" 19HA1003].
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