Evidence map›Paper›PMID 35300074›Full record

ArticleCurrent research in pharmacology and drug discovery2022

Regulation of bFGF-induced effects on rat aortic smooth muscle cells by β

Yingzi Chang, Lei Alena Dagat, Aisha Yusuf, Yusuf Zahriya, Kotryna Staputyte, Emma Worley, Alex Holt, Natalie Canuteson, Vereena Messieha, Kasey Halila

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in pharmacology and drug discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yingzi ChangDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Lei Alena DagatDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Aisha YusufDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Yusuf ZahriyaDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Kotryna StaputyteDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Emma WorleyTruman State University, Kirksville, MO, 63501, USA.
Alex HoltDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Natalie CanutesonDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Vereena MessiehaDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
Kasey HalilaDepartment of Pharmacology, A.T. Still University, Kirksville College of Osteopathic Medicine, Kirksville, MO, 63501, USA.
A.T. Still University · USTruman State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Basic fibroblast growth factor (bFGF)-mediated vascular smooth muscle cell (VSMC) proliferation and migration play an important role in vascular injury-induced neointima formation and subsequent vascular restenosis, a major event that hinders the long-term success of angioplasty. The function of β Objectives: Our current study explored the possible role of β Methods: β Results: We found that vascular injury induced upregulation of β Conclusion: Our results suggest that activation of β

Indexed as

bFGF, basic fibroblast growth factorCL316,243ERK/AKT phosphorylationERK/MAPK, extracellular-signal-regulated kinase/mitogen activated protein kinaseNeointimaPI3K/AKT, phosphatidylinositol 3-kinase and Akt (protein kinase B)VSMC migrationVSMC proliferationVSMC, vascular smooth muscle cellβ3-AR, β3-adrenergic receptor

Identifiers

PMID35300074
PMCPMC8920869
OpenAlexW4221055822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.