ReviewJournal of lifestyle medicine2022
Effect of Exercises on Central and Endocrine System for Pain Modulation in Primary Dysmenorrhea.
Review in Journal of lifestyle medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06233786 (Effectiveness of Non-invasive Neuromodulation in Primary Dysmenhorrea), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Non-invasive Neuromodulation in Primary Dysmenhorrea: A Randomized Clinical Trial
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The effectiveness of aerobic exercise on pain and disability in individuals with neck pain: A systematic review and meta-analysis.Experimental physiology · 2026Pooled it
- Aerobic exercise to alleviate primary dysmenorrhea in adolescents and young women: A systematic review and meta-analysis of randomized controlled trials.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- The Effect of Aviva Exercise Intervention on Pain Level and Body Awareness in Women with Primary Dysmenorrhea.Medicina (Kaunas, Lithuania) · 2024Trial
- Impact of traditional Chinese Baduanjin exercise on menstrual health among international female students studying in China: a randomized controlled trial.Frontiers in public health · 2024Trial
- The Sprint-Interval Exercise Using a Spinning Bike Improves Physical Fitness and Ameliorates Primary Dysmenorrhea Symptoms Through Hormone and Inflammation Modulations: A Randomized Controlled Trial.Journal of sports science & medicine · 2022Trial
- Effectiveness of Therapeutic Exercise in Reducing the Severity of Primary Dysmenorrhea and Associated Symptoms: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Self-Reported Dysmenorrhea Among Adolescent Girls in the Cape Coast Metropolis: A Cross-Sectional Study.Health science reports · 2026Article
- Factors Associated with Severe Primary Dysmenorrhea in Adolescent Girls: A Retrospective Single-Center Study.Journal of pain research · 2026Article
- Endogenous mediators in regulating primary dysmenorrhea.Frontiers in cell and developmental biology · 2026Review
- The Influence of the Menstrual Cycle on Electrical Thresholds for Sensory and Pain Perception: Implications for Exercise and Rehabilitation in Women With and Without Primary Dysmenorrhea-A Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Traditional Chinese medicine treatment strategies for primary dysmenorrhea.Frontiers in endocrinology · 2025Review
- Mobile applications available in Saudi Arabia for the management of Primary Dysmenorrhea: A quality review and content analysis.PloS one · 2025Article
- Ginger Moxibustion Activates TRPV1 to Modulate the Locus Coeruleus-Spinal Cord-Uterus Pathway and Alleviates Primary Dysmenorrhea in Rats.Journal of pain research · 2025Article
- Comparative effect of Kegel and Pelvic rocking exercises on primary dysmenorrhea: A quasi-experimental study.Bioinformation · 2025Article
- The Role of Physical Exercise in Chronic Musculoskeletal Pain: Best Medicine-A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- Transcutaneous Tibial Nerve Stimulation for Primary Dysmenorrhea: A Protocol for a Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysmenorrhea is the term for describing complex menstrual flow and painful spasmodic cramps during menstruation, and pain without any pathology is considered Primary Dysmenorrhea (PD). It is the most frequent ailment among women of all ages and races. The pain is dull and throbbing in character and occurs in the lower back and abdomen. Symptoms commonly appear 6 to 12 months after menarche, with the most significant incidence in the late teen and early twenties. Physical exercise is nearly a new non-medical intervention to relieve PD associated pain. Aerobics, stretching and Resistive exercises for 8-12 weeks, either supervised or unsupervised, relieves pain. Exercises are believed to cause hormonal changes in the uterine lining, which reduces PD symptoms. Researchers have presumed different pain-relieving methods, ranging from non-opioids to opioids to hormonal for variations in pain sensitivity. Exercise-induced analgesia provides the central pathway as the primary mechanism for pain reduction while, another way to reducing pain in PD may be a hormonal interaction. The hormonal changes causing exercise-induced pain modulation during the menstruation cycle is not clearly understood and the interaction and activation of all the central and endocrine components, which is a complex mechanism, is also not explained clearly. This study briefly reviews the physiological mechanism of Exercise-induced analgesia and its potent roles in controlling the pathogenesis of PD for pain relief.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.