Evidence map›Paper›PMID 35299966›Full record

ArticleFrontiers in endocrinology2022

A Cohort Study on the Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients With Breast Cancer; Does Trastuzumab Interfere With the Outcome?

Maryam Joudi, Maryam Moradi Binabaj, Pejman Porouhan, Babak PeyroShabany, Mohsen Tabasi, Danial Fazilat-Panah, Mahtab Khajeh, Arezoo Mehrabian, Mansoureh Dehghani, James S Welsh and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  10. Review
  11. Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people with gastrointestinal cancer.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Observational
  12. The Effects of the COVID-19 Pandemic in Oncology Patient Management.International journal of environmental research and public health · 2022
    Article
  13. Review
  14. Article
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  18. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Maryam JoudiDepartment of Pediatrics, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Maryam Moradi BinabajCellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Pejman PorouhanDepartment of Radiation Oncology, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Babak PeyroShabanyDepartment of Internal Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Mohsen TabasiCenter for Inflammation and Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Danial Fazilat-PanahCancer Research Center, Babol University of Medical Sciences, Babol, Iran.
Mahtab KhajehVasei Clinical Research Development Unit, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Arezoo MehrabianStudent Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Mansoureh DehghaniDepartment of Radiation Oncology, Neyshabur University of Medical Sciences, Neyshabur, Iran.
James S WelshDepartment of Radiation Oncology, Edward Hines Jr VA Hospital and Stritch School of Medicine, Loyola University Chicago, Chicago, IL, United States.
Batol KeykhosraviVasei Clinical Research Development Unit, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Azam Akbari YazdiVasei Clinical Research Development Unit, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Mona AriamaneshDepartment of Pathology, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Ahmad GhasemiDepartment of Basic Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Gordon FernsDepartment of Medical Education, Brighton and Sussex Medical School, Brighton, United Kingdom.
Seyed Alireza JavadiniaVasei Clinical Research Development Unit, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Sabzevar University of Medical Sciences · IRUniversity of Neyshabur · IRBabol University of Medical Sciences · IRBrighton and Sussex Medical School · GBEdward Hines, Jr. VA Hospital · USIran University of Medical Sciences · IRTemple University · USZabol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer. Methods: In this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 ± 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects. Results: The presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7%, 87.4%, and 93.3%. The prevalence of COVID-19 infection after vaccination was 0.7%, 0% and 0% for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3% and 24.3% of patients, respectively. Discussion: The inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.

Indexed as

Breast NeoplasmsCOVID-19AdultAntibodies, ViralCohort StudiesCOVID-19 VaccinesFemaleHumansMiddle AgedRNA, ViralSARS-CoV-2TrastuzumabAntibodies, ViralCOVID-19 VaccinesRNA, ViralTrastuzumabbreast cancercancerCOVID-19 vaccineinactivated SARS-CoV-2 vaccineIranmalignancySARS-CoV2seroconversion

Identifiers

PMID35299966
PMCPMC8923352
OpenAlexW4214601771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.