Evidence map›Paper›PMID 35299960›Full record

ArticleFrontiers in endocrinology2022

miR-218-5p Induces Interleukin-1β and Endovascular Trophoblast Differentiation by Targeting the Transforming Growth Factor β-SMAD2 Pathway.

Yanan Shan, Yan Chen, Jelena Brkić, Leslie Fournier, Haiying Ma, Chun Peng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanan ShanDepartment of Biology, York University, Toronto, ON, Canada.
Yan ChenDepartment of Biology, York University, Toronto, ON, Canada.
Jelena BrkićDepartment of Biology, York University, Toronto, ON, Canada.
Leslie FournierDepartment of Biology, York University, Toronto, ON, Canada.
Haiying MaDepartment of Biology, York University, Toronto, ON, Canada.
Chun PengDepartment of Biology, York University, Toronto, ON, Canada.
York University · CA

Funding

CIHR PJT-153146
6 · The paper itself

Abstract

The acquisition of an endovascular trophoblast (enEVT) phenotype is essential for normal placental development and healthy pregnancy. MicroRNAs (miRNAs) are small noncoding RNAs that play critical roles in regulating gene expression. We have recently reported that miR-218-5p promotes enEVT differentiation and spiral artery remodeling in part by targeting transforming growth factor β2 (TGFβ2). We also identified

Indexed as

MicroRNAsTrophoblasts3' Untranslated RegionsFemaleHumansInterleukin-1betaPlacentaPregnancySmad2 Protein3' Untranslated RegionsInterleukin-1betaMicroRNAsMIRN218 microRNA, humanSmad2 ProteinSMAD2 protein, humanendovascular trophoblastIL1βmiR-218-5pplacentaSMADTGFβ

Identifiers

PMID35299960
PMCPMC8920978
OpenAlexW4214601089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.